- What is Leigh's disease (Leigh's syndrome)?
- What causes Leigh's disease?
- What are the symptoms of Leigh's disease?
- Is there any treatment for Leigh's disease?
- Are there other forms of Leigh's disease?
- What is the prognosis for Leigh's disease?
- What research is being done with Leigh's disease?
- Clinical trials for Leigh's disease
- Support for Leigh's disease
- Find a local Doctor in your town
What is Leigh's Disease?
Leigh's disease is a rare inherited neurometabolic disorder that affects the central nervous system. This progressive disorder begins in infants between the ages of three months and two years. Rarely, it occurs in teenagers and adults.
What causes Leigh's disease?
Leigh's disease can be caused by mutations in mitochondrial DNA or by deficiencies of an enzyme called pyruvate dehydrogenase.
What are the symptoms of Leigh's disease?
Symptoms of Leigh's disease usually progress rapidly. The earliest signs may be poor sucking ability, and the loss of head control and motor skills. These symptoms may be accompanied by loss of appetite, vomiting, irritability, continuous crying, and seizures. As the disorder progresses, symptoms may also include generalized weakness, lack of muscle tone, and episodes of lactic acidosis, which can lead to impairment of respiratory and kidney function.
In Leigh's disease, genetic mutations in mitochondrial DNA interfere with the energy sources that run cells in an area of the brain that plays a role in motor movements. The primary function of mitochondria is to convert the energy in glucose and fatty acids into a substance called adenosine triphosphate (ATP). The energy in ATP drives virtually all of a cell's metabolic functions. Genetic mutations in mitochondrial DNA, therefore, result in a chronic lack of energy in these cells, which in turn affects the central nervous system and causes progressive degeneration of motor functions.
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