Lescol XL (cont.)

What Are Warnings and Precautions for Lescol XL?

This medication contains fluvastatin. Do not take Lescol XL if you are allergic to fluvastatin or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

Patients taking fluvastatin should not combine this drug with gemfibrozil or red yeast rice because of increased risk for muscle pain and muscle damage.

Cautions

• Non-serious and reversible cognitive side effects may occur
• Increased blood sugar and glycosylated hemoglobin (HbA1c) levels reported with statin intake
• Heavy alcohol use, history of liver disease, renal failure
• Myopathy, risk of myopathy may be increased by co-administration w/ fibrates, niacin, cyclosporine, macrolides, azole antifungals.
• Withhold or discontinue treatment if myopathy develops, renal failure, or transaminase levels >3 times the upper limit of normal
• Rare reports of immune-mediated necrotizing myopathy (IMNM), characterized by increased serum creatine kinase that persist despite discontinuing statin
• Lipid-lowering effects additive with bile-acid binding resin or niacin
• Take 2 hours after bile acid sequestrant

Pregnancy and Lactation

Breastfeeding mothers should not use Lescol XL or fluvastatin. Because the risks outweigh the potential benefits of taking this drug, pregnant women should avoid Lescol XL (fluvastatin). Safer alternative are available.

Medical Editor: John P. Cunha, DO, FACOEP

SOURCE:

Medscape. Lescol XL. Fluvastatin.

http://reference.medscape.com/drug/lescol-xl-fluvastatin-342456

REFERENCE:

U.S. Food and Drug Adminstration