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Leucovorin Calcium Injection

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Leucovorin Calcium Injection

LEUCOVORIN (leucovorin calcium)
Calcium Injection USP

LEUCOVORIN (leucovorin calcium)
Calcium for Injection

DRUG DESCRIPTION

Leucovorin (leucovorin calcium) is one of several active, chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists.

Also known as folinic acid, Citrovorum factor, or 5-formyl-5,6,7,8-tetrahydrofolic acid, this compound has the chemical designation of Calcium N-[p-[[[(6RS)-2- amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl]methyl]amino]benzoyl]-L-glutamate (1:1). The structural formula of leucovorin (leucovorin calcium) calcium is:

Leucovorin Calcium Structural Formula Illustration

C20H21CaN7O7...........................................M.W.=511.51

Leucovorin (leucovorin calcium) Calcium Injection USP is a sterile, preservative-free solution indicated for intramuscular (IM) or intravenous (IV) administration in a 50 mL single-dose vial. Each mL contains leucovorin (leucovorin calcium) calcium equivalent to 10 mg Leucovorin (leucovorin calcium) , USP; 8 mg sodium chloride; sodium hydroxide and/or hydrochloric acid for pH adjustment pH 7.8 (6.5 to 8.5).

There is 0.004 mEq of calcium per mg of leucovorin (leucovorin calcium) . Solution contains no bacteriostat or antimicrobial agents.

Leucovorin (leucovorin calcium) Calcium for Injection is a sterile product indicated for intramuscular (IM) or intravenous (IV) administration and is supplied in 50 mg, 100 mg, 200 mg, and 350 mg vials.

Each 50 mg vial of Leucovorin (leucovorin calcium) Calcium for Injection, when reconstituted with 5 mL of sterile diluent, contains leucovorin (leucovorin calcium) (as the calcium salt) 10 mg/mL.

Each 100 mg vial of Leucovorin (leucovorin calcium) Calcium for Injection, when reconstituted with 10 mL of sterile diluent, contains leucovorin (leucovorin calcium) (as the calcium salt) 10 mg/mL.

Each 200 mg vial of Leucovorin (leucovorin calcium) Calcium for Injection, when reconstituted with 20 mL of sterile diluent, contains leucovorin (leucovorin calcium) (as the calcium salt) 10 mg/mL.

Each 350 mg vial of Leucovorin (leucovorin calcium) Calcium for Injection, when reconstituted with 17.5 mL of sterile diluent, contains leucovorin (leucovorin calcium) (as the calcium salt) 20 mg/mL.

In each dosage form, one milligram of leucovorin (leucovorin calcium) calcium contains 0.002 mmol of leucovorin (leucovorin calcium) and 0.002 mmol of calcium.

These lyophilized products contain no preservative. The inactive ingredient is Sodium Chloride, USP, added to adjust tonicity. Reconstitute with Bacteriostatic Water for Injection, USP, which contains benzyl alcohol (see WARNINGS), or with Sterile Water for Injection, USP.

Last reviewed on RxList: 2/24/2009
This monograph has been modified to include the generic and brand name in many instances.

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