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Leukeran

Last reviewed on RxList: 3/3/2017
Leukeran Side Effects Center

Last reviewed on RxList 7/29/2016

 

Leukeran (chlorambucil) Tablets is an anticancer drug used to treat several types of cancer including Hodgkin's disease, leukemia, and lymphoma. Common side effects of Leukeran include nausea, vomiting, diarrhea, tremors or shaking, numbness, burning, pain, and tingling feeling. Tell your doctor if you experience serious side effects of Leukeran including seizures (convulsions); fever, chills, body aches, flu symptoms, sores in your mouth and throat, pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; sore throat, and headache with a severe blistering, peeling, and red skin rash; itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); an unusual mass or lump; chest discomfort, dry cough or hack, persistent cough; shortness of breath on exertion; weakness or tiredness, rapid weight loss; severe nausea, vomiting, or diarrhea; or missed menstrual periods.

The usual dosage of Leukeran is 0.1 to 0.2 mg/kg body weight daily for 3 to 6 weeks. Talk to your doctor about your individual dosage recommendation. There may be other drugs that interact with Leukeran. Tell your doctor all medications you use. Leukeran may lower your body's immune system. It may also cause infertility in men and women. Do not take Leukeran if you are pregnant or breastfeeding.

Our Leukeran (chlorambucil) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Leukeran Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking chlorambucil and call your doctor at once if you have a serious side effect such as:

  • seizure (convulsions);
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat, ongoing cough;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • an unusual mass or lump;
  • chest discomfort, dry cough or hack;
  • feeling short of breath on exertion;
  • feeling weak or tired, loss of appetite, rapid weight loss;
  • severe nausea, vomiting, or diarrhea; or
  • missed menstrual periods.

Less serious side effects:

  • mild nausea, vomiting, or diarrhea;
  • tremors or shaking; or
  • numbness, burning, pain, or tingly feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Leukeran (Chlorambucil)

Leukeran Professional Information

SIDE EFFECTS

Hematologic

The most common side effect is bone marrow suppression, anemia, leukopenia, neutropenia, thrombocytopenia, or pancytopenia. Although bone marrow suppression frequently occurs, it is usually reversible if the chlorambucil is withdrawn early enough. However, irreversible bone marrow failure has been reported.

Gastrointestinal

Gastrointestinal disturbances such as nausea and vomiting, diarrhea, and oral ulceration occur infrequently.

CNS4

Tremors, muscular twitching, myoclonia, confusion, agitation, ataxia, flaccid paresis, and hallucinations have been reported as rare adverse experiences to chlorambucil which resolve upon discontinuation of drug. Rare, focal and/or generalized seizures have been reported to occur in both children and adults at both therapeutic daily doses and pulse-dosing regimens, and in acute overdose (see PRECAUTIONS: General).

Dermatologic

Allergic reactions such as urticaria and angioneurotic edema have been reported following initial or subsequent dosing. Skin hypersensitivity (including rare reports of skin rash progressing to erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson syndrome) has been reported (see WARNINGS).

Miscellaneous

Other reported adverse reactions include: pulmonary fibrosis, hepatotoxicity and jaundice, drug fever, peripheral neuropathy, interstitial pneumonia, sterile cystitis, infertility, leukemia, and secondary malignancies (see WARNINGS).

Read the entire FDA prescribing information for Leukeran (Chlorambucil)

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© Leukeran Patient Information is supplied by Cerner Multum, Inc. and Leukeran Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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