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Leukeran

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Leukeran

Leukeran Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Leukeran (chlorambucil) Tablets is an anticancer drug used to treat several types of cancer including Hodgkin's disease, leukemia, and lymphoma. Common side effects of Leukeran include nausea, vomiting, diarrhea, tremors or shaking, numbness, burning, pain, and tingling feeling.

The usual dosage of Leukeran is 0.1 to 0.2 mg/kg body weight daily for 3 to 6 weeks. Talk to your doctor about your individual dosage recommendation. There may be other drugs that interact with Leukeran. Tell your doctor all medications you use. Leukeran may lower your body's immune system. It may also cause infertility in men and women. Do not take Leukeran if you are pregnant or breastfeeding.

Our Leukeran (chlorambucil) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Leukeran in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking chlorambucil and call your doctor at once if you have a serious side effect such as:

  • seizure (convulsions);
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat, ongoing cough;
  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • an unusual mass or lump;
  • chest discomfort, dry cough or hack;
  • feeling short of breath on exertion;
  • feeling weak or tired, loss of appetite, rapid weight loss;
  • severe nausea, vomiting, or diarrhea; or
  • missed menstrual periods.

Less serious side effects:

  • mild nausea, vomiting, or diarrhea;
  • tremors or shaking; or
  • numbness, burning, pain, or tingly feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Leukeran (Chlorambucil) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Leukeran Overview - Patient Information: Side Effects

SIDE EFFECTS: See also Warnings section.

Nausea, vomiting, stomach upset, diarrhea, and loss of appetite may occur. Changes in diet such as eating several small meals or limiting physical activity may help lessen the chance of nausea. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: mouth sores, shaking/tremors, muscle problems (e.g., twitching, stiffness, weakness), unsteadiness, joint pain, lower back pain/side pain, frequent/painful urination, numbness/tingling of the hands or feet, swelling of the legs/feet, mental/mood changes (e.g., confusion, hallucinations), stopping of menstrual periods.

Tell your doctor immediately if any of these rare but very serious side effects occur: seizures, trouble breathing, severe stomach/abdominal pain, yellowing of the skin/eyes, dark urine, inability to move arms/legs.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Leukeran (Chlorambucil)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Leukeran FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

Hematologic

The most common side effect is bone marrow suppression, anemia, leukopenia, neutropenia, thrombocytopenia, or pancytopenia. Although bone marrow suppression frequently occurs, it is usually reversible if the chlorambucil is withdrawn early enough. However, irreversible bone marrow failure has been reported.

Gastrointestinal

Gastrointestinal disturbances such as nausea and vomiting, diarrhea, and oral ulceration occur infrequently.

CNS4

Tremors, muscular twitching, myoclonia, confusion, agitation, ataxia, flaccid paresis, and hallucinations have been reported as rare adverse experiences to chlorambucil which resolve upon discontinuation of drug. Rare, focal and/or generalized seizures have been reported to occur in both children and adults at both therapeutic daily doses and pulse-dosing regimens, and in acute overdose (see PRECAUTIONS: General).

Dermatologic

Allergic reactions such as urticaria and angioneurotic edema have been reported following initial or subsequent dosing. Skin hypersensitivity (including rare reports of skin rash progressing to erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson syndrome) has been reported (see WARNINGS).

Miscellaneous

Other reported adverse reactions include: pulmonary fibrosis, hepatotoxicity and jaundice, drug fever, peripheral neuropathy, interstitial pneumonia, sterile cystitis, infertility, leukemia, and secondary malignancies (see WARNINGS).

Read the entire FDA prescribing information for Leukeran (Chlorambucil) »

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Leukeran - User Reviews

Leukeran User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Leukeran sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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