home > drugs a-z list > leukine (sargramostim) drug center > leukine (sargramostim) drug - patient how to take

In this Article

• What is sargramostim (Leukine)?
• What are the possible side effects of sargramostim (Leukine)?
• What is the most important information I should know about sargramostim (Leukine)?
• What should I discuss with my healthcare provider before using sargramostim (Leukine)?
• How should I use sargramostim (Leukine)?
• What happens if I miss a dose (Leukine)?
• What happens if I overdose (Leukine)?
• What should I avoid while using sargramostim (Leukine)?
• What other drugs will affect sargramostim (Leukine)?
• Where can I get more information?

What should I discuss with my healthcare provider before using sargramostim (Leukine)?

Do not use sargramostim without first talking to your doctor if you have an allergy to yeast. You may have an allergic reaction to this medication.

Before using sargramostim, tell your doctor if you

• are undergoing radiation or chemotherapy;
• have asthma or another lung disease;
• have heart disease, especially an irregular heartbeat or congestive heart failure;
• have fluid retention;
• have myeloid (bone marrow) cancer;
• have kidney disease; or
• have liver disease.

You may not be able to use sargramostim or you may require a dosage adjustment or special monitoring if you have any of the conditions listed above.

Sargramostim is in the FDA pregnancy category C. This means that it is not known whether sargramostim will be harmful to an unborn baby. Do not use sargramostim without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether sargramostim passes into breast milk. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.

How should I use sargramostim (Leukine)?

Use sargramostim exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Sargramostim can be used subcutaneously (SC) or intravenously (IV). Your doctor, nurse, or pharmacist will give you specific instructions on how and where to inject the medication.

Do not administer an injection if you are unsure how it should be injected, how much to inject, or how often to inject the medication. Call your doctor, nurse, or pharmacist to go over the instructions with you.

Rotate injection sites as directed and inject the medication slowly.

Do not shake any vial of sargramostim. It can be gently swirled if mixing is needed.

The powdered form of Leukine must be reconstituted (mixed) with sterile water, or bacteriostatic water to form a solution for injection. Solutions made with sterile water (no preservative) must be used within 6 hours of mixing, then thrown away. Leukine Liquid and solutions mixed with bacteriostatic water can be kept for up to 20 days under refrigeration.

The vial of medication can be allowed to reach room temperature by leaving it out of the refrigerator for about 30 minutes before injecting a dose. Do not leave the vial in direct sunlight.

Properly store and discard all syringes and needles.

It is important to use sargramostim regularly to get the most benefit.

Your doctor may want you to have blood tests or other medical evaluations during treatment with sargramostim to monitor progress and side effects.

Store this medication in the refrigerator between 2 and 8 degrees Celsius (36 to 46 degrees Fahrenheit) away from light, moisture, and the reach of children. Discard all medication on the expiration date.