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home > drugs a-z list > leustatin (cladribine) drug center > leustatin (cladribine) drug - overdosage and contraindications
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Leustatin
Leukemia facts
- Leukemia is a cancer of the blood cells.
- While the exact cause(s) of leukemia is not known, risk factors have been identified.
- Leukemias are grouped by how quickly the disease develops (acute or chronic) as well as by the type of blood cell that is affected (lymphocytes or myelocytes). The four main types of leukemia include acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myelocytic leukemia (AML), and chronic myelocytic leukemia (CML).
- People with leukemia are at significantly increased risk for developing infections, anemia, and bleeding. Other symptoms and signs include easy bruising, weight loss, night sweats, and unexplained fevers.
- The diagnosis of leukemia is supported by findings of the
medical history and examination, and examining blood
and bone marrow samples under a microscope.
- Tre...
Leustatin
OVERDOSE
High doses of LEUSTATIN (cladribine) have been associated with: irreversible neurologic toxicity (paraparesis/quadriparesis), acute nephrotoxicity, and severe bone marrow suppression resulting in neutropenia, anemia and thrombocytopenia (see WARNINGS). There is no known specific antidote to overdosage. Treatment of overdosage consists of discontinuation of LEUSTATIN (cladribine) , careful observation and appropriate supportive measures. It is not known whether the drug can be removed from the circulation by dialysis or hemofiltration.
CONTRAINDICATIONS
LEUSTATIN (cladribine) Injection is contraindicated in those patients who are hypersensitive to this drug or any of its components.
Last reviewed on RxList: 10/23/2008
This monograph has been modified to include the generic and brand name in many instances.
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