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Leustatin Patient Information including How Should I Take

What should I discuss with my healthcare provider before receiving cladribine (Leustatin)?

You should not use this medication if you are allergic to it.

If you have liver or kidney disease or a bone marrow problem, you may need a dose adjustment or special tests to safely receive cladribine.

FDA pregnancy category D. Do not use cladribine if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether cladribine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving cladribine.

How is cladribine given (Leustatin)?

Cladribine is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Cladribine must be given slowly through an IV infusion, and you will receive it around the clock for 7 days in a row. Your doctor will determine how many 7-day treatments you will receive and how often.

You may receive other medications to help prevent certain side effects of cladribine.

Cladribine can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill.

To be sure this medication is not causing harmful effects, your blood will need to be tested often. Your liver or kidney function may also need to be tested. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.

Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, pale skin, easy bruising or bleeding (nosebleeds, bleeding gums), purple or red pinpoint spots under your skin, loss of appetite, mouth sores, or unusual weakness.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Women's Health

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