"The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the marketing of selexipag (Uptravi, Actelion Registration Ltd) for the treatment of adults with pulmonary arterial hypertension (PAH)./"...
There is no actual experience with levatol® overdose. The signs and symptoms that would be expected with overdosage of β-adrenergic receptor antagonists are symptomatic bradycardia, hypotension, bronchospasm, and acute cardiac failure. In addition to discontinuation of levatol®, gastric emptying, and close observation of the patient, the following measures might be considered as appropriate:
Administer atropine sulfate to induce vagal blockade. If bradycardia persists, intravenous isoproterenol hydrochloride may be administered cautiously; larger than usual doses may be needed. In refractory cases, the use of a trans venous cardiac pacemaker may be necessary.
Sympathomimetic drug therapy, such as dopamine, dobutamine, or levarterenol, may be considered if hypotension persists despite correction of bradycardia. In refractory cases, administration of glucagon hydrochloride has been reported to be useful.
A β-2-agonist or isoproterenol hydrochloride may be administered. Additional therapy with aminophylline may be considered.
Acute Cardiac Failure
Institute conventional therapy immediately. Intravenous administration of dobutamine and glucagon hydrochloride has been reported to be useful.
Heart Block (Second or Third Degree)
Isoproterenol hydrochloride or a transvenous cardiac pacemaker may be used.
levatol® is contraindicated in patients with cardiogenic shock, sinus bradycardia, second and third degree atrioventricular conduction block, bronchial asthma, and those with known hypersensitivity to this product (see WARNINGS).This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 6/10/2011
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