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(levorphanol tartrate) Injection, Solution and Tablet
Levo-Dromoran (levorphanol tartrate) is a potent opioid analgesic with empirical formula C17H23NO•C4H6O6•2H2O and molecular weight 443.5. Each mg of levorphanol tartrate is equivalent to 0.58 mg levorphanol base. Chemically levorphanol is levo-3-hydroxy-N-methylmorphinan. The USP nomenclature is 17-methylmorphinan 3-ol tartrate (1:1)(Salt) dihydrate. The material has 3 asymmetric carbon atoms. The chemical structure is:
Levorphanol tartrate is a white crystalline powder, soluble in water and ether but insoluble in chloroform.
Each 1-mL ampul contains 2 mg levorphanol tartrate, 1.8 mg methyl paraben preservative, 0.2 mg propyl paraben preservative, sodium hydroxide to adjust pH to approximately 4.3 and Water for Injection.
Each milliliter in the 10 mL vials contains 2 mg levorphanol tartrate, 4.5 mg phenol preservative, sodium hydroxide to adjust pH to approximately 4.3 and Water for Injection.
What are the possible side effects of levorphanol (Levo-Dromoran)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- mood changes, confusion, unusual thoughts or behavior;
- thoughts of suicide or hurting yourself;
- feeling like you might pass out;
- weak or shallow breathing;
- cold, clammy skin;
- blue lips or skin;
- painful or difficult urination; or
- slow heart rate, weak pulse, fainting, slow breathing...
What are the precautions when taking levorphanol (Levo Dromoran)?
Before taking levorphanol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor, increased intracranial pressure), heart problems (e.g., irregular heartbeat), low blood pressure, certain bowel diseases (e.g., paralytic ileus, toxic megacolon), breathing problems (e.g., asthma, chronic obstructive pulmonary disease-COPD, emphysema, low oxygen/high carbon dioxide in the blood), disease of the pancreas (e.g., pancreatitis), mental/mood disorders (e.g.,...
Last reviewed on RxList: 6/3/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Levo Dromoran Information
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