May 28, 2017
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"Vemurafenib (Zelboraf, Roche/Genentech), a BRAF inhibitor marketed for use in the treatment of melanoma, has now shown activity in patients with refractory papillary thyroid cancer.

For the approximately 25% to 50% of patients "...




Patients should be informed of the following information to aid in the safe and effective use of Levo-T™ (levothyroxine sodium tablets) :

  • Notify your physician if you are allergic to any foods or medicines, are pregnant or intend to become pregnant, are breast-feeding or are taking any other medications, including prescription and over-the-counter preparations.
  • Notify your physician of any other medical conditions you may have, particularly heart disease, diabetes, clotting disorders, and adrenal or pituitary gland problems. Your dose of medications used to control these other conditions may need to be adjusted while your are taking Levo-T™ (levothyroxine sodium tablets) . If you have diabetes, monitor your blood and/or urinary glucose levels as directed by your physician and immediately report any changes to your physician. If you are taking anticoagulants (blood thinners), your clotting status should be checked frequently.
  • Use Levo-T™ (levothyroxine sodium tablets) only as prescribed by your physician. Do not discontinue or change the amount you take or how often you take it, unless directed to do so by your physician.
  • The levothyroxine in Levo-T™ (levothyroxine sodium tablets) is intended to replace a hormone that is normally produced by your thyroid gland. Generally, replacement therapy is to be taken for life, except in cases of transient hypothyroidism, which is usually associated with an inflammation of the thyroid gland (thyroiditis).
  • Take Levo-T™ (levothyroxine sodium tablets) in the morning on an empty stomach, at least one-half hour before eating any food.
  • It may take several weeks before you notice an improvement in your symptoms.
  • Notify your physician if you experience any of the following symptoms: rapid or irregular heartbeat, chest pain, shortness of breath, leg cramps, headache, nervousness, irritability, sleeplessness, tremors, change in appetite, weight gain or loss, vomiting, diarrhea, excessive sweating, heat intolerance, fever, changes in menstrual periods, hives or skin rash, or any other unusual medical event.
  • Notify your physician if you become pregnant while taking Levo-T™ (levothyroxine sodium tablets) . It is likely that your dose of Levo-T™ (levothyroxine sodium tablets) will need to be increased while you are pregnant.
  • Notify your physician or dentist that you are taking Levo-T™ (levothyroxine sodium tablets) prior to any surgery.
  • Partial hair loss may occur rarely during the first few months of Levo-T™ (levothyroxine sodium tablets) therapy, but this is usually temporary.
  • Levo-T™ (levothyroxine sodium tablets) should not be used as a primary or adjunctive therapy in a weight control program.
  • Keep Levo-T™ (levothyroxine sodium tablets) out of the reach of children. Store Levo-T™ (levothyroxine sodium tablets) away from heat, moisture, and light.

Last reviewed on RxList: 7/10/2008
This monograph has been modified to include the generic and brand name in many instances.

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