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Levoleucovorin

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Levoleucovorin

Levoleucovorin
Injection, Powder, Lyophilized, for Solution for Intravenous use

DRUG DESCRIPTION

levoleucovorin is the levo isomeric form of racemic d,l-leucovorin, present as the calcium salt. levoleucovorin is the pharmacologically active isomer of leucovorin [(6-S)-leucovorin].

levoleucovorin for injection contains levoleucovorin calcium, which is one of several active, chemically reduced derivatives of folic acid. It is useful as antidote to the inhibition of dihydrofolate reductase by methotrexate. This compound has the chemical designation calcium (6S)-N-{4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl] amino]benzoyl-L-glutamate pentahydrate. The molecular weight is 601.6 and the structural formula is:

levoleucovorin (injection) Structural Formula Illustration

Its molecular formula is: C20H21CaN7O7 5 H2O.

levoleucovorin for injection is supplied as a sterile lyophilized powder consisting of 64 mg levoleucovorin calcium pentahydrate (equivalent to 50 mg levoleucovorin) and 50 mg mannitol per 50 mg vial.

Sodium hydroxide and/or hydrocholoric acid are used to adjust the pH during manufacture. It is intended for intravenous administration after reconstitution with 5.3 mL of sterile 0.9% Sodium Chloride Injection, USP [See DOSAGE AND ADMINISTRATION]

What are the possible side effects of levoleucovorin (Fusilev)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor or caregivers at once if you have a serious side effect such as:

  • white patches or sores inside your mouth or on your lips;
  • urinating more or less than usual;
  • severe or ongoing diarrhea;
  • feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
  • fever, chills;
  • confusion; or
  • trouble breathing.

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Read All Potential Side Effects and See Pictures of Levoleucovorin »

Last reviewed on RxList: 3/31/2008
This monograph has been modified to include the generic and brand name in many instances.

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