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Levophed

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Levophed

LEVOPHED
(norepinephrine bitartrate) Injection, Solution, Concentrate

DRUG DESCRIPTION

Norepinephrine (sometimes referred to as l-arterenol/Levarterenol or l-norepinephrine) is a sympathomimetic amine which differs from epinephrine by the absence of a methyl group on the nitrogen atom.

Norepinephrine Bitartrate is (-)-α-(aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate and has the following structural formula:

LEVOPHED (norepinephrine bitartrate)  structural formula illustration

LEVOPHED (norepinephrine bitartrate) is supplied in sterile aqueous solution in the form of the bitartrate salt to be administered by intravenous infusion following dilution. Norepinephrine is sparingly soluble in water, very slightly soluble in alcohol and ether, and readily soluble in acids. Each mL contains the equivalent of 1 mg base of norepinephrine, sodium chloride for isotonicity, and not more than 0.2 mg of sodium metabisulfite as an antioxidant. It has a pH of 3 to 4.5. The air in the vials has been displaced by nitrogen gas.

What are the possible side effects of norepinephrine (Levophed Bitartrate)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • pain, burning, irritation, discoloration, or skin changes where the injection is given;
  • sudden numbness, weakness, or cold feeling anywhere in your body;
  • slow or uneven heart rate;
  • blue lips or fingernails, mottled skin;
  • urinating less than usual or not at all;
  • trouble...

Read All Potential Side Effects and See Pictures of Levophed »

Last reviewed on RxList: 12/2/2010
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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