"The U.S. Food and Drug Administration today approved Northera capsules (droxidopa) for the treatment of neurogenic orthostatic hypotension (NOH). NOH is a rare, chronic and often debilitating drop in blood pressure upon standing that is associate"...
(norepinephrine bitartrate) Injection, Solution, Concentrate
Norepinephrine (sometimes referred to as l-arterenol/Levarterenol or l-norepinephrine) is a sympathomimetic amine which differs from epinephrine by the absence of a methyl group on the nitrogen atom.
Norepinephrine Bitartrate is (-)-α-(aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate and has the following structural formula:
LEVOPHED (norepinephrine bitartrate) is supplied in sterile aqueous solution in the form of the bitartrate salt to be administered by intravenous infusion following dilution. Norepinephrine is sparingly soluble in water, very slightly soluble in alcohol and ether, and readily soluble in acids. Each mL contains the equivalent of 1 mg base of norepinephrine, sodium chloride for isotonicity, and not more than 0.2 mg of sodium metabisulfite as an antioxidant. It has a pH of 3 to 4.5. The air in the vials has been displaced by nitrogen gas.
What are the possible side effects of norepinephrine (Levophed Bitartrate)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:
- muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, nausea with vomiting;
- fast, slow, or uneven heart rate;
- blue lips or fingernails, mottled skin;
- urinating less than usual or not at all;
- irritation of the skin or vein where the medicine is...
Last reviewed on RxList: 12/2/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Levophed Information
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