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Levophed

Last reviewed on RxList: 5/2/2016
Levophed Side Effects Center

Last reviewed on RxList 9/28/2016

Levophed (norepinephrine bitartrate) is a vasoconstrictor, similar to adrenaline, used to treat life-threatening low blood pressure (hypotension) that can occur with certain medical conditions or surgical procedures. Levophed is often used during or after CPR (cardio-pulmonary resuscitation). Levophed is available in generic form. Tell your doctor if you have serious side effects of Levophed include:

  • dizziness,
  • weakness,
  • headache,
  • slow heart rate,
  • breathing difficulty, or
  • redness and swelling at the injection site.

Serious side effects of Levophed include:

  • pain or burning where the injection is given,
  • sudden numbness/weakness/cold feeling in your body,
  • blue lips or fingernails,
  • urinating less than usual or not at all,
  • trouble breathing,
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, irregular heartbeats, seizure).

Levophed is diluted in liquid and given continuously into a large vein (IV infusion), as directed by the doctor. Dosage is based on the patient's condition and response to treatment. Levophed may interact with blood pressure medications, MAO inhibitors, or antidepressants. Tell your doctor all medications you use. During pregnancy, Levophed should be used only if prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Levophed (norepinephrine bitartrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Levophed Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • pain, burning, irritation, discoloration, or skin changes where the injection is given;
  • sudden numbness, weakness, or cold feeling anywhere in your body;
  • slow or uneven heart rate;
  • blue lips or fingernails, mottled skin;
  • urinating less than usual or not at all;
  • trouble breathing;
  • problems with vision, speech, or balance; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Levophed (Norepinephrine Bitartrate)

Levophed Professional Information

SIDE EFFECTS

The following reactions can occur:

Body As A Whole: Ischemic injury due to potent vasoconstrictor action and tissue hypoxia.

Cardiovascular System: Bradycardia, probably as a reflex result of a rise in blood pressure, arrhythmias.

Nervous System: Anxiety, transient headache.

Respiratory System: Respiratory difficulty.

Skin and Appendages: Extravasation necrosis at injection site.

Prolonged administration of any potent vasopressor may result in plasma volume depletion which should be continuously corrected by appropriate fluid and electrolyte replacement therapy. If plasma volumes are not corrected, hypotension may recur when LEVOPHED is discontinued, or blood pressure may be maintained at the risk of severe peripheral and visceral vasoconstriction (e.g., decreased renal perfusion) with diminution in blood flow and tissue perfusion with subsequent tissue hypoxia and lactic acidosis and possible ischemic injury. Gangrene of extremities has been rarely reported.

Overdoses or conventional doses in hypersensitive persons (e.g., hyperthyroid patients) cause severe hypertension with violent headache, photophobia, stabbing retrosternal pain, pallor, intense sweating, and vomiting.

Read the entire FDA prescribing information for Levophed (Norepinephrine Bitartrate)

Related Resources for Levophed

© Levophed Patient Information is supplied by Cerner Multum, Inc. and Levophed Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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