Levophed Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Levophed (norepinephrine bitartrate) is used to treat life-threatening low blood pressure (hypotension) that can occur with certain medical conditions or surgical procedures. This medication is often used during CPR (cardio-pulmonary resuscitation). It is a vasoconstrictor, similar to adrenaline. This medication is available in generic form. Common side effects include dizziness, weakness, headache, slow heart rate, breathing difficulty, or redness and swelling at the injection site.
Levophed is diluted in liquid and given continuously into a large vein (IV infusion), as directed by the doctor. Dosage is based on the patient's condition and response to treatment. Levophed may interact with blood pressure medications, MAO inhibitors, or antidepressants. Tell your doctor all medications you use. During pregnancy, Levophed should be used only if prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.
Our Levophed (norepinephrine bitartrate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Levophed in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have any of these serious side effects:
- muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, nausea with vomiting;
- fast, slow, or uneven heart rate;
- blue lips or fingernails, mottled skin;
- urinating less than usual or not at all;
- irritation of the skin or vein where the medicine is injected;
- sudden numbness or weakness, especially on one side of the body; or
- sudden headache, confusion, problems with vision, speech, or balance.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Levophed (Norepinephrine Bitartrate) »
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Levophed FDA Prescribing Information: Side Effects
The following reactions can occur:
Body As A Whole: Ischemic injury due to potent vasoconstrictor action and tissue hypoxia.
Nervous System: Anxiety, transient headache.
Respiratory System: Respiratory difficulty.
Skin and Appendages: Extravasation necrosis at injection site.
Prolonged administration of any potent vasopressor may result in plasma volume depletion which should be continuously corrected by appropriate fluid and electrolyte replacement therapy. If plasma volumes are not corrected, hypotension may recur when LEVOPHED (norepinephrine bitartrate) is discontinued, or blood pressure may be maintained at the risk of severe peripheral and visceral vasoconstriction (e.g., decreased renal perfusion) with diminution in blood flow and tissue perfusion with subsequent tissue hypoxia and lactic acidosis and possible ischemic injury. Gangrene of extremities has been rarely reported.
Overdoses or conventional doses in hypersensitive persons (e.g., hyperthyroid patients) cause severe hypertension with violent headache, photophobia, stabbing retrosternal pain, pallor, intense sweating, and vomiting.
Read the entire FDA prescribing information for Levophed (Norepinephrine Bitartrate) »
Additional Levophed Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Find out what women really need.