Lexiscan overdosage may result in serious reactions [see WARNINGS AND PRECAUTIONS]. In a study of healthy volunteers, symptoms of flushing, dizziness and increased heart rate were assessed as intolerable at Lexiscan doses greater than 0.02 mg/kg.
Aminophylline to Reverse Effects
Methylxanthines, such as caffeine, aminophylline, and theophylline, are competitive adenosine receptor antagonists and aminophylline has been used to terminate persistent pharmacodynamic effects. Aminophylline may be administered in doses ranging from 50 mg to 250 mg by slow intravenous injection (50 mg to 100 mg over 30–60 seconds). Methylxanthine use is not recommended in patients who experience a seizure in association with Lexiscan administration.
Do not administer Lexiscan to patients with:
- Second-or third-degree AV block, or
- sinus node dysfunction
unless these patients have a functioning artificial pacemaker [see WARNINGS AND PRECAUTIONS].
Last reviewed on RxList: 10/3/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Lexiscan Information
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