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This drug should not be used with the following medications because very serious interactions may occur: alfuzosin, cisapride, delavirdine, ergot drugs (e.g., dihydroergotamine, ergotamine), etravirine, midazolam, pimozide, ranolazine, certain rifamycins (rifampin, rifapentine), certain "statin" drugs for cholesterol (lovastatin, simvastatin), St John's wort, triazolam.

If you are currently using any of these medications, tell your doctor or pharmacist before starting fosamprenavir.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other anti-HIV drugs (such as amprenavir, efavirenz, indinavir, lopinavir/ritonavir, nelfinavir, nevirapine, saquinavir), anti-anxiety drugs (e.g., alprazolam, diazepam), artemether-lumefantrine, bosentan, atorvastatin, rosuvastatin, azole antifungals (e.g., ketoconazole, itraconazole), calcium channel blockers (e.g., diltiazem, nifedipine, verapamil), colchicine, dexamethasone, drugs to treat erectile dysfunction/pulmonary hypertension (such as sildenafil, tadalafil, vardenafil), erythromycin, ethinyl estradiol, fluticasone, drugs that suppress the immune system (e.g., cyclosporine, tacrolimus, rapamycin), drugs for irregular heartbeat (e.g., amiodarone, flecainide, IV lidocaine, propafenone, quinidine), garlic supplements, methadone, paroxetine, rifabutin, salmeterol, anti-seizure drugs (e.g., carbamazepine, phenobarbital, phenytoin), temsirolimus, trazodone, tricyclic antidepressants (e.g., amitriptyline), anti-ulcer medicines (e.g., H2 blockers such as ranitidine, cimetidine), warfarin.

This medication may cause hormonal birth control (pills, patch, ring) to work less well. This effect can result in pregnancy. To help prevent pregnancy and reduce the risk of spreading HIV to others, always use effective barrier protection (latex or polyurethane condoms, dental dams) during all sexual activity (see also Notes section). Consult your doctor or pharmacist for details.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

NOTES: Ask your doctor how you can lower your risk of heart disease (for example - weight loss, controlling high blood pressure, stop smoking).

Patients treated with fosamprenavir may continue to acquire "opportunistic" infections associated with HIV. This medication does not prevent the transmission of HIV to others through sexual contact or blood. Practice "safe sex" (including the use of latex condoms) to minimize the risk of transmitting the virus to others.

Do not share this medication with others.

Laboratory and/or medical tests (e.g., liver function, triglycerides/cholesterol, white blood cell counts-WBC, blood sugar) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is more than 4 hours after your scheduled dose, skip the missed dose and resume your usual dosing schedule. It is important not to miss doses of this drug.

STORAGE: Store the tablet form in a tightly closed container between 59-86 degrees F (15-30 degrees C) away from light and moisture.

Store the liquid form in a tightly closed container between 41-86 degrees F (5-30 degrees C) away from light. Refrigeration may improve the taste of the liquid medication. Do not freeze.

Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854- 1166 (USA) or 1-800-668-1507 (Canada).

Information last revised September 2010 Copyright(c) 2010 First DataBank, Inc.