Librax

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Librax

Librax Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Librax (chlordiazepoxide HCI clidinium bromide) is used to treat stomach ulcers, irritable bowel syndrome, and intestinal infections. Chlordiazepoxide is a benzodiazepine and clindinium is an anticholinergic/spasmolytic. The brand name Librex is no longer available in the U.S. This medication may be available in generic form. Common side effects include dizziness, drowsiness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating.

The dosage of chlordiazepoxide and clidinium varies with the diagnosis and response of the individual patient. The usual maintenance dose is 1 or 2 capsules (5 mg chlordiazepoxide hydrochloride and 2.5 mg clidinium bromide), 3 or 4 times a day administered before meals and at bedtime. Chlordiazepoxide and clidinium may interact with barbiturates, blood thinners, MAO inhibitors, medicines to treat psychiatric disorders, narcotics, or antidepressants. Tell your doctor all medications you use. Chlordiazepoxide and clidinium is not recommended for use during pregnancy. It may harm a fetus. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended. This medication may be habit-forming. Withdrawal symptoms may occur if this drug is stopped abruptly.

Our Librax (chlordiazepoxide HCI clidinium bromide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Librax in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • confusion;
  • depressed mood, thoughts of suicide or hurting yourself;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • hyperactivity, agitation, hostility;
  • hallucinations;
  • jaundice (yellowing of the skin or eyes); or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • drowsiness, tiredness;
  • swelling;
  • skin rash;
  • blurred vision;
  • dry mouth;
  • nausea, vomiting, constipation; or
  • irregular menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Librax (Chlordiazepoxide and Clidinium) »

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Librax Overview - Patient Information: Side Effects

SIDE EFFECTS: Dizziness, drowsiness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. To relieve dry eyes, consult your pharmacist for artificial tears or other eye lubricants.

To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: decreased sweating, dry/hot/flushed skin, fast/irregular heartbeat, loss of coordination, slurred speech, fainting, uncontrollable/unusual muscle movements, mental/mood changes (such as confusion, agitation, unusual excitement, depression, strange thoughts), eye pain, vision changes, difficulty urinating, decreased sexual ability, slow/shallow breathing.

Tell your doctor immediately if any of these rare but serious side effects occur: signs of infection (such as fever, persistent sore throat), signs of liver problems (dark urine, persistent nausea, vomiting, stomach/abdominal pain, yellowing eyes/skin, unusual tiredness).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Librax (Chlordiazepoxide and Clidinium)»

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Librax FDA Prescribing Information: Side Effects
(Adverse Reactions)

SIDE EFFECTS

No side effects or manifestations not seen with either compound alone have been reported with the administration of Librax (chlordiazepoxide and clidinium) . However, since Librax (chlordiazepoxide and clidinium) contains chlordiazepoxide hydrochloride and clidinium bromide, the possibility of untoward effects which may be seen with either of these two compounds cannot be excluded.

When chlordiazepoxide hydrochloride has been used alone the necessity of discontinuing therapy because of undesirable effects has been rare. Drowsiness, ataxia and confusion have been reported in some patients - particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.

Other adverse reactions reported during therapy with chlor-diazepoxide hydrochloride include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extrapyramidal symptoms, as well as increased and decreased libido. Such side effects have been infrequent and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after chlor-diazepoxide hydrochloride treatment.

Blood dyscrasias, including agranulocytosis, jaundice and hepatic dysfunction have occasionally been reported during therapy with chlordiazepoxide hydrochloride. When chlor-diazepoxide hydrochloride treatment is protracted, periodic blood counts and liver function tests are advisable.

Adverse effects reported with use of Librax (chlordiazepoxide and clidinium) are those typical of anticolinergic agents, ie, dryness of the mouth, blurring of vision, urinary hesitancy and constipation. Constipation has occurred most often when Librax (chlordiazepoxide and clidinium) therapy has been combined with other spasmolytic agents and/or a low residue diet.

Drug Abuse And Dependence

Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of chlordiazepoxide. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving chlordiazepoxide or other psychotropic agents because of the predisposition of such patients to habituation and dependence.

Read the entire FDA prescribing information for Librax (Chlordiazepoxide and Clidinium) »

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Librax - User Reviews

Librax User Reviews

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Here is a collection of user reviews for the medication Librax sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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