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Librax

Last reviewed on RxList: 3/27/2017
Please Note: This Brand Name drug is no longer available in the US. (Generic versions may still be available.)
Librax Side Effects Center

Last reviewed on RxList 03/27/2017

Librax (chlordiazepoxide and clidinium bromide) is a combination of a benzodiazepine and an anticholinergic/spasmolytic used to treat stomach ulcers, irritable bowel syndrome, and intestinal infections. The brand name Librax is no longer available in the U.S. Generic versions may be available. Common side effects of Librax (chlordiazepoxide and clidinium bromide) include:

  • dizziness,
  • drowsiness,
  • tiredness,
  • weakness,
  • blurred vision,
  • dry eyes,
  • dry mouth,
  • nausea,
  • vomiting,
  • constipation,
  • abdominal bloating,
  • swelling,
  • skin rash, and
  • irregular menstrual periods.

Tell your doctor if you have unlikely but serious side effects of Librax (chlordiazepoxide and clidinium bromide) including:

  • decreased sweating,
  • dry/hot/flushed skin,
  • fast or irregular heartbeat,
  • loss of coordination,
  • slurred speech,
  • fainting,
  • uncontrollable or unusual muscle movements,
  • mental/mood changes (such as confusion, agitation, unusual excitement, depression, or strange thoughts),
  • difficulty urinating,
  • decreased sexual ability, or
  • slow or shallow breathing.

The dosage of chlordiazepoxide and clidinium varies with the diagnosis and response of the individual patient. The usual maintenance dose is 1 or 2 capsules (5 mg chlordiazepoxide hydrochloride and 2.5 mg clidinium bromide), 3 or 4 times a day administered before meals and at bedtime. Chlordiazepoxide and clidinium may interact with barbiturates, blood thinners, MAO inhibitors, medicines to treat psychiatric disorders, narcotics, or antidepressants. Tell your doctor all medications you use. Chlordiazepoxide and clidinium is not recommended for use during pregnancy. It may harm a fetus. This medication passes into breast milk and may have undesirable effects on a nursing infant. Breastfeeding while using this drug is not recommended. This medication may be habit-forming. Withdrawal symptoms may occur if this drug is stopped abruptly.

Our Librax (chlordiazepoxide HCI clidinium bromide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Librax Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • confusion;
  • depressed mood, thoughts of suicide or hurting yourself;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • hyperactivity, agitation, hostility;
  • hallucinations;
  • jaundice (yellowing of the skin or eyes); or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • drowsiness, tiredness;
  • swelling;
  • skin rash;
  • blurred vision;
  • dry mouth;
  • nausea, vomiting, constipation; or
  • irregular menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Librax (Chlordiazepoxide and Clidinium)

Librax Professional Information

SIDE EFFECTS

No side effects or manifestations not seen with either compound alone have been reported with the administration of Librax. However, since Librax contains chlordiazepoxide hydrochloride and clidinium bromide, the possibility of untoward effects which may be seen with either of these two compounds cannot be excluded.

When chlordiazepoxide hydrochloride has been used alone the necessity of discontinuing therapy because of undesirable effects has been rare. Drowsiness, ataxia and confusion have been reported in some patients - particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.

Other adverse reactions reported during therapy with chlordiazepoxide hydrochloride include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extrapyramidal symptoms, as well as increased and decreased libido. Such side effects have been infrequent and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after chlordiazepoxide hydrochloride treatment.

Blood dyscrasias, including agranulocytosis, jaundice and hepatic dysfunction have occasionally been reported during therapy with chlordiazepoxide hydrochloride. When chlordiazepoxide hydrochloride treatment is protracted, periodic blood counts and liver function tests are advisable.

Adverse effects reported with use of Librax are those typical of anticholinergic agents, i.e., dryness of the mouth, blurring of vision, urinary hesitancy and constipation. Constipation has occurred most often when Librax therapy has been combined with other spasmolytic agents and/or a low residue diet.

To report SUSPECTED ADVERSE REACTIONS, contact Valeant Pharmaceuticals North America LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Drug Abuse And Dependence

Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of chlordiazepoxide. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (e.g., dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving chlordiazepoxide or other psychotropic agents because of the predisposition of such patients to habituation and dependence.

Read the entire FDA prescribing information for Librax (Chlordiazepoxide and Clidinium)

Related Resources for Librax

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© Librax Patient Information is supplied by Cerner Multum, Inc. and Librax Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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