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Librium (chlordiazepoxide) is indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal" symptoms of acute alcoholism, and preoperative apprehension and anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
The effectiveness of Librium (chlordiazepoxide) in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
DOSAGE AND ADMINISTRATION
Because of the wide range of clinical indications for Librium (chlordiazepoxide) , the optimum dosage varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects.
|ADULTS||USUAL DAILY DOSE|
|Relief of Mild and Moderate Anxiety Disorders and Symptoms of Anxiety||5 mg or 10 mg, 3 or 4 times daily|
|Relief of Severe Anxiety Disorders and Symptoms of Anxiety||20 mg or 25 mg, 3 or 4 times daily|
|Geriatric Patients, or in the presence of debilitating disease.||5 mg, 2 to 4 times daily|
|PEDIATRIC PATIENTS||USUAL DAILY DOSE|
|Because of the varied response of pediatric patients to CNS-acting drugs, therapy should be initiated with the lowest dose and increased as required. Since clinical experience in pediatric patients under 6 years of age is limited, the use of the drug in this age group is not recommended.||5 mg, 2 to 4 times daily (may be increased in some pediatric patients to 10 mg, 2 to 3 times daily)|
For the relief of withdrawal symptoms of acute alcoholism, the parenteral form* is usually used initially. If the drug is administered orally, the suggested initial dose is 50 to 100 mg, to be followed by repeated doses as needed until agitation is controlled up to 300 mg per day. Dosage should then be reduced to maintenance levels.
* See package insert for Injectable Librium (chlordiazepoxide HCI).
Librium (chlordiazepoxide HCI) Capsules are available in the following presentations:
5 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3750-10), with LIBRIUM (chlordiazepoxide)
5 imprinted on the opaque green cap and ICN imprinted on the opaque yellow body.
10 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3751-10), with LIBRIUM (chlordiazepoxide) 10 imprinted on the opaque black cap and ICN imprinted on the opaque green body.
25 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3758-10), with LIBRIUM (chlordiazepoxide) 25 imprinted on the opaque green cap and ICN imprinted on the opaque white body.
Store at 25°C (77°F); excursions permitted to 15°C - 30°C (59°F - 86°F).
Vaieant Pharmaceuticals International Costa Mesa, CA 92626. Rev. July 2005. FDA rev date: 9/6/2002
Last reviewed on RxList: 10/19/2010
This monograph has been modified to include the generic and brand name in many instances.
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