Lidoderm (Lidocaine Patch 5%) Drug Information: Overdosage and Contraindications

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May 27, 2012

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Shingles facts

Shingles is caused by the same virus that causes chickenpox and can be spread to people who have not had chickenpox.
Shingles, also known as herpes zoster, is not related to the sexually transmitted herpes virus disease called herpes genitalis, or the oral herpes virus, herpes simplex.
Shingles may cause pain that can continue after the rash disappears.
Steroids and antiviral drugs can help prevent long-term pain after shingles if they are started within the first two days of the appearance of the rash.
The Zostavax vaccine is available for people over 60 years of age to reduce the incidence and severity of shingles.

What is shingles? What causes shingles?

Shingles is a skin rash caused by a nerve and skin inflammation from the same virus that previously caused chickenpox. This virus is called the varicella zoster virus (VZV) and b...

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OVERDOSE

Lidocaine overdose from cutaneous absorption is rare, but could occur. If there is any suspicion of lidocaine overdose (see ADVERSE REACTIONS, Systemic Reactions), drug blood concentration should be checked. The management of overdose includes close monitoring, supportive care, and symptomatic treatment. Dialysis is of negligible value in the treatment of acute overdose with lidocaine.

In the absence of massive topical overdose or oral ingestion, evaluation of symptoms of toxicity should include consideration of other etiologies for the clinical effects, or overdosage from other sources of lidocaine or other local anesthetics.

The oral LD50 of lidocaine HCl is 459 (346-773) mg/kg (as the salt) in non-fasted female rats and 214 (159-324) mg/kg (as the salt) in fasted female rats, which are equivalent to roughly 4000 mg and 2000 mg, respectively, in a 60 to 70 kg man based on the equivalent surface area dosage conversion factors between species.

CONTRAINDICATIONS

LIDODERM (lidocaine patch 5%) is contraindicated in patients with a known history of sensitivity to local anesthetics of the amide type, or to any other component of the product.

Last reviewed on RxList: 1/24/2011
This monograph has been modified to include the generic and brand name in many instances.