Lidoderm (Lidocaine Patch 5%) Drug Information: Side Effects and Drug Interactions

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May 27, 2012

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Shingles is caused by the same virus that causes chickenpox and can be spread to people who have not had chickenpox.
Shingles, also known as herpes zoster, is not related to the sexually transmitted herpes virus disease called herpes genitalis, or the oral herpes virus, herpes simplex.
Shingles may cause pain that can continue after the rash disappears.
Steroids and antiviral drugs can help prevent long-term pain after shingles if they are started within the first two days of the appearance of the rash.
The Zostavax vaccine is available for people over 60 years of age to reduce the incidence and severity of shingles.

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Shingles is a skin rash caused by a nerve and skin inflammation from the same virus that previously caused chickenpox. This virus is called the varicella zoster virus (VZV) and b...

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SIDE EFFECTS

Application Site Reactions

During or immediately after treatment with LIDODERM (lidocaine patch 5%), the skin at the site of application may develop blisters, bruising, burning sensation, depigmentation, dermatitis, discoloration, edema, erythema, exfoliation, irritation, papules, petechia, pruritus, vesicles, or may be the locus of abnormal sensation. These reactions are generally mild and transient, resolving spontaneously within a few minutes to hours.

Allergic Reactions

Allergic and anaphylactoid reactions associated with lidocaine, although rare, can occur. They are characterized by angioedema, bronchospasm, dermatitis, dyspnea, hypersensitivity, laryngospasm, pruritus, shock, and urticaria. If they occur, they should be managed by conventional means. The detection of sensitivity by skin testing is of doubtful value.

Other Adverse Events

Due to the nature and limitation of spontaneous reports in postmarketing surveillance, causality has not been established for additional reported adverse events including:

Asthenia, confusion, disorientation, dizziness, headache, hyperesthesia, hypoesthesia, lightheadedness, metallic taste, nausea, nervousness, pain exacerbated, paresthesia, somnolence, taste alteration, vomiting, visual disturbances such as blurred vision, flushing, tinnitus, and tremor.

Systemic (Dose-Related) Reactions

Systemic adverse reactions following appropriate use of LIDODERM (lidocaine patch 5%) are unlikely, due to the small dose absorbed (see CLINICAL PHARMACOLOGY, Pharmacokinetics). Systemic adverse effects of lidocaine are similar in nature to those observed with other amide local anesthetic agents, including CNS excitation and/or depression (light headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest). Excitatory CNS reactions may be brief or not occur at all, in which case the first manifestation may be drowsiness merging into unconsciousness. Cardiovascular manifestations may include bradycardia, hypotension and cardiovascular collapse leading to arrest.

DRUG INTERACTIONS

Antiarrhythmic Drugs: LIDODERM (lidocaine patch 5%) should be used with caution in patients receiving Class I antiarrhythmic drugs (such as tocainide and mexiletine) since the toxic effects are additive and potentially synergistic.

Local Anesthetics: When LIDODERM (lidocaine patch 5%) is used concomitantly with other products containing local anesthetic agents, the amount absorbed from all formulations must be considered.

Last reviewed on RxList: 1/24/2011
This monograph has been modified to include the generic and brand name in many instances.