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Both components of LIMBITROL (chlordiazepoxide amitriptyline ds tablets) exert their action in the central nervous system. Extensive studies with chlordiazepoxide in many animal species suggest action in the limbic system. Recent evidence indicates that the limbic system is involved in emotional response. Taming action was observed in some species. The mechanism of action of amitriptyline in man is not known, but the drug appears to interfere with the reuptake of norepinephrine into adrenergic nerve endings. This action may prolong the sympathetic activity of biogenic amines.

Last reviewed on RxList: 5/11/2009
This monograph has been modified to include the generic and brand name in many instances.

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