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Limbitrol

Last reviewed on RxList: 5/5/2016
Limbitrol Side Effects Center

Last reviewed on RxList 2/19/2016

Limbitrol (chlordiazepoxide amitriptyline ds tablets) is a combination of a benzodiazepine and a tricyclic antidepressant used to treat depression, anxiety, and tension. Common side effects of Limbitrol include dry mouth, dizziness, drowsiness, restlessness, tiredness, constipation, loss of appetite, bloating, strange dreams or nightmares, stuffy nose, blurred vision, decreased sex drive, impotence, or difficulty having an orgasm.

Our Limbitrol (chlordiazepoxide amitriptyline ds tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Limbitrol Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

  • confusion, hallucinations, unusual thoughts or behavior;
  • feeling light-headed, fainting;
  • seizure (convulsions);
  • weak or shallow breathing;
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
  • sudden numbness or weakness (especially on one side of the body), headache, confusion, problems with vision, speech, or balance.

Less serious side effects may include:

  • dry mouth, stuffy nose, blurred vision;
  • dizziness, drowsiness;
  • feeling restless or tired;
  • constipation, bloating, loss of appetite;
  • strange dreams or nightmares; or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Limbitrol (Chlordiazepoxide Amitriptyline DS Tablets)

Limbitrol Professional Information

SIDE EFFECTS

Adverse reactions to LIMBITROL are those associated with the use of either component alone. Most frequently reported were drowsiness, dry mouth, constipation, blurred vision, dizziness and bloating. Other side effects occurring less commonly included vivid dreams, impotence, tremor, confusion and nasal congestion. Many symptoms common to the depressive state, such as anorexia, fatigue, weakness, restlessness and lethargy, have been reported as side effects of treatment with both LIMBITROL and amitriptyline.

Granulocytopenia, jaundice and hepatic dysfunction of uncertain etiology have also been observed rarely with LIMBITROL. When treatment with LIMBITROL is prolonged, periodic blood counts and liver function tests are advisable.

Note: Included in the listing which follows are adverse reactions which have not been reported with LIMBITROL. However, they are included because they have been reported during therapy with one or both of the components or closely related drugs.

Cardiovascular

Hypotension, hypertension, tachycardia, palpitations, myocardial infarction, arrhythmias, heart block, stroke.

Psychiatric

Euphoria, apprehension, poor concentration, delusions, hallucinations, hypomania and increased or decreased libido.

Neurologic

Incoordination, ataxia, numbness, tingling and paresthesias of the extremities, extrapyramidal symptoms, syncope, changes in EEG patterns.

Anticholinergic

Disturbance of accommodation, paralytic ileus, urinary retention, dilatation of urinary tract.

Allergic

Skin rash, urticaria, photosensitization, edema of face and tongue, pruritus.

Hematologic

Bone marrow depression including agranulocytosis, eosinophilia, purpura, thrombocytopenia.

Gastrointestinal

Nausea, epigastric distress, vomiting, anorexia, stomatitis, peculiar taste, diarrhea, black tongue.

Endocrine

Testicular swelling and gynecomastia in the male, breast enlargement, galactorrhea and minor menstrual irregularities in the female, elevation and lowering of blood sugar levels, and syndrome of inappropriate ADH (antidiuretic hormone) secretion.

Other

Headache, weight gain or loss, increased perspiration, urinary frequency, mydriasis, jaundice, alopecia, parotid swelling.

Drug Abuse And Dependence

Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of chlordiazepoxide. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Withdrawal symptoms (e.g., nausea, headache and malaise) have also been reported in association with abrupt amitriptyline discontinuation. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving chlordiazepoxide or other psychotropic agents because of the predisposition of such patients to habituation and dependence.

Read the entire FDA prescribing information for Limbitrol (Chlordiazepoxide Amitriptyline DS Tablets)

Related Resources for Limbitrol

Read the Limbitrol User Reviews »

© Limbitrol Patient Information is supplied by Cerner Multum, Inc. and Limbitrol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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