"Sept. 23, 2014 -- Every year, 13 million to 14 million Americans have major depression. Of those who seek treatment, 30% to 40% will not get better or fully recover with standard antidepressants.
That puts them at greater risk of alcohol "...
Limbitrol Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Limbitrol (chlordiazepoxide amitriptyline ds tablets) is used to treat depression, anxiety and tension. Amitriptyline is a tricyclic antidepressant. Chlordiazepoxide is a benzodiazepine. Common side effects include dry mouth, dizziness, drowsiness, feeling restless or tired, constipation, strange dreams, or decreased sex drive.
Limbitrol is taken by mouth 1 to 4 times daily or as directed by your doctor. Limbitrol may interact with other medications, including antiplatelet drugs (clopidogrel, NSAIDs such as ibuprofen, "blood thinners" such as warfarin), drugs for high blood pressure (clonidine, guanabenz, reserpine), bronchodilators/decongestants/stimulants, celecoxib (Celebrex), cimetidine (Tagamet), ADHD medications (Adderall, Ritalin, Strattera), cancer medications, heart rhythm medications, HIV medications, medicine to treat or prevent nausea and vomiting, medicine to treat psychiatric disorders, narcotics, or thyroid supplements. Tell your doctor all medications you take. If you are pregnant or think you may be pregnant, discuss with your doctor the benefits and risks of using this medication. This medication passes into breast milk. Consult your doctor before breastfeeding.
Our Limbitrol (chlordiazepoxide amitriptyline ds tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Limbitrol in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have a serious side effect such as:
- confusion, hallucinations, unusual thoughts or behavior;
- feeling light-headed, fainting;
- seizure (convulsions);
- weak or shallow breathing;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or
- sudden numbness or weakness (especially on one side of the body), headache, confusion, problems with vision, speech, or balance.
Less serious side effects may include:
- dry mouth, stuffy nose, blurred vision;
- dizziness, drowsiness;
- feeling restless or tired;
- constipation, bloating, loss of appetite;
- strange dreams or nightmares; or
- decreased sex drive, impotence, or difficulty having an orgasm.
Read the entire detailed patient monograph for Limbitrol (Chlordiazepoxide Amitriptyline DS Tablets)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Limbitrol Overview - Patient Information: Side Effects
Drowsiness, dizziness, dry mouth, blurred vision, constipation, bloating, trouble urinating, and weight gain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
To reduce the risk of dizziness and fainting, get up slowly when rising from a sitting or lying position.
To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bruising/bleeding, loss of balance, persistent heartburn, mental/mood changes (such as confusion, excitement, memory problems, suicidal thoughts), shaking (tremor), decreased sexual ability/desire, signs of infection (such as fever, persistent sore throat), persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, yellowing eyes/skin.
Get medical help right away if you have any very serious side effects, including: black stools, chest pain, severe dizziness, fainting, fast/irregular heartbeat, seizures, slurred speech, weakness on one side of the body, eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night), vomit that looks like coffee grounds.
A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Limbitrol (Chlordiazepoxide Amitriptyline DS Tablets)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Limbitrol FDA Prescribing Information: Side Effects
Adverse reactions to LIMBITROL (chlordiazepoxide amitriptyline ds tablets) are those associated with the use of either component alone. Most frequently reported were drowsiness, dry mouth, constipation, blurred vision, dizziness and bloating. Other side effects occurring less commonly included vivid dreams, impotence, tremor, confusion and nasal congestion. Many symptoms common to the depressive state, such as anorexia, fatigue, weakness, restlessness and lethargy, have been reported as side effects of treatment with both LIMBITROL (chlordiazepoxide amitriptyline ds tablets) and amitriptyline.
Granulocytopenia, jaundice and hepatic dysfunction of uncertain etiology have also been observed rarely with LIMBITROL (chlordiazepoxide amitriptyline ds tablets) . When treatment with LIMBITROL (chlordiazepoxide amitriptyline ds tablets) is prolonged, periodic blood counts and liver function tests are advisable.
Note: Included in the listing which follows are adverse reactions which have not been reported with LIMBITROL (chlordiazepoxide amitriptyline ds tablets) . However, they are included because they have been reported during therapy with one or both of the components or closely related drugs.
Testicular swelling and gynecomastia in the male, breast enlargement, galactorrhea and minor menstrual irregularities in the female, elevation and lowering of blood sugar levels, and syndrome of inappropriate ADH (antidiuretic hormone) secretion.
Drug Abuse And Dependence
Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of chlordiazepoxide. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Withdrawal symptoms (e.g., nausea, headache and malaise) have also been reported in association with abrupt amitriptyline discontinuation. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving chlordiazepoxide or other psychotropic agents because of the predisposition of such patients to habituation and dependence.
Read the entire FDA prescribing information for Limbitrol (Chlordiazepoxide Amitriptyline DS Tablets)
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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