Limonene

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Are there any interactions with medications?



Medications changed by the liver (Cytochrome P450 2C9 [CYP2C9] substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Limonene might increase how quickly the liver breaks down some medications. Taking limonene along with some medications that are changed by the liver can lead to a variety of effects and side effects. Before taking limonene talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene), amitriptyline (Elavil), warfarin (Coumadin), glipizide (Glucotrol), losartan (Cozaar), and others.



Medications that decrease the breakdown of other medications by the liver (Cytochrome P450 2C19 [CYP2C19] inhibitors)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Limonene might be broken down by the liver. Taking limonene along with medications that decrease the break down of limonene in the liver might increase the effects and side effects of limonene.

Some medications that might decrease the breakdown of limonene in the liver include cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), and others.



Medications that decrease the breakdown of other medications by the liver (Cytochrome P450 2C9 [CYP2C9] inhibitors)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Limonene might be broken down by the liver. Taking limonene along with medications that decrease the break down of limonene in the liver might increase the effects and side effects of limonene.

Some medications that might decrease the breakdown of limonene in the liver include amiodarone (Cordarone), fluconazole (Diflucan), lovastatin (Mevacor), paroxetine (Paxil), zafirlukast (Accolate), and many others.



Medications that increase the breakdown of other medications by the liver (Cytochrome P450 2C19 [CYP2C19] inducers)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Limonene might be broken down by the liver. Taking limonene along with medications that increase the breakdown of limonene in the liver might decrease the effects of limonene.

Some medications that might increase the breakdown of limonene in the liver include carbamazepine (Tegretol), prednisone (Deltasone), and rifampin (Rifadin, Rimactane).



Medications that increase the breakdown of other medications by the liver (Cytochrome P450 2C9 [CYP2C9] inducers)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Limonene might be broken down by the liver. Taking limonene along with medications that increase the breakdown of limonene in the liver might decrease the effects of limonene.

Some medications that might increase the breakdown of limonene in the liver include rifampin (Rifadin, Rimactane) and secobarbital (Seconal).

Dosing considerations for Limonene.

The appropriate dose of limonene depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for limonene. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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