Recommended Topic Related To:


"June 24, 2014 -- Scientists say they may be able to explain how ongoing stress raises the risk of having a heart attack.

They say stress triggers our bodies to make a surplus of disease-fighting white blood cells. That in turn can boost inf"...



Intramuscular administration of a single dose of 600 mg of lincomycin produces average peak serum levels of 11.6 g/mL at 60 minutes and maintains therapeutic levels for 17 to 20 hours for most susceptible gram-positive organisms. Urinary excretion after this dose ranges from 1.8 to 24.8 percent (mean: 17.3 percent).

A two hour intravenous infusion of 600 mg of lincomycin achieves average peak serum levels of 15.9 g/mL and yields therapeutic levels for 14 hours for most susceptible gram-positive organisms. Urinary excretion ranges from 4.9 to 30.3 percent (mean: 13.8 percent).

The biological half-life after intramuscular or intravenous administration is 5.4 1.0 hours. The serum half-life of lincomycin may be prolonged in patients with severe impairment of renal function compared to patients with normal renal function. In patients with abnormal hepatic function, serum half-life may be twofold longer than in patients with normal hepatic function. Hemodialysis and peritoneal dialysis are not effective in removing lincomycin from the serum.

Tissue level studies indicate that bile is an important route of excretion. Significant levels have been demonstrated in the majority of body tissues. Although lincomycin appears to diffuse into cerebrospinal fluid (CSF), levels of lincomycin in the CSF appear inadequate for the treatment of meningitis.

Microbiology: Lincomycin has been shown to be active against most strains of the following organisms both in vitroand in clinical infections: (see INDICATIONS AND USAGE).

  Staphylococcus aureus (penicillinase- and non-penicillinase producing strains)
  Streptococcus pneumoniae

The following in vitro data are available; but their clinical significance is unknown.

Lincomycin has been shown to be active in vitro against the following microorganisms; however, the safety and efficacy of LINCOCIN (lincomycin hcl) in treating clinical infections due to these organisms have not been established in adequate and well controlled trials.

Aerobic gram-positive cocci:

   Streptococcus pyogenes
Viridans group streptococci

Aerobic gram-positive bacilli:

   Corynebacterium diphtheriae

Anaerobic gram-positive non-sporeforming bacilli:

   Propionibacterium acnes

Anaerobic gram-positive sporeforming bacilli:

   Clostridium tetani
   Clostridium perfringens

This drug is not active against most strains of Enterococcus faecalis nor against

Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae or other gram-negative organisms or yeasts.

Cross resistance has been demonstrated between clindamycin and lincomycin. Some cross resistance with erythromycin including a phenomenon known as dissociated cross resistance or macrolide effect has been reported.

Studies indicate that lincomycin does not share antigenicity with penicillin compounds.

Animal Pharmacology

In vivoexperimental animal studies demonstrated the effectiveness of LINCOCIN preparations (lincomycin) in protecting animals infected with Streptococcus viridans, β-hemolytic Streptococcus, Staphylococcus aureus, Diplococcus pneumoniae and Leptospira pomona. It was ineffective in Klebsiella, Pasteurella, Pseudomonas, Salmonella and Shigella infections.

Clinical Studies

Experience with 345 obstetrical patients receiving this drug revealed no ill effects related to pregnancy.

Last reviewed on RxList: 4/7/2008
This monograph has been modified to include the generic and brand name in many instances.


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Heart Health

Get the latest treatment options.