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The following reactions have been reported with the use of lincomycin:
Gastrointestinal-Glossitis, stomatitis, nausea, vomiting, antibiotic-associated diarrhea and colitis, and pruritus ani. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment (see WARNINGS).
Hematopoietic-Neutropenia, leukopenia, agranulocytosis and thrombocytopenic purpura have been reported. There have been rare reports of aplastic anemia and pancytopenia in which LINCOCIN (lincomycin hcl) could not be ruled out as the causative agent.
Hypersensitivity Reactions-Hypersensitivity reactions such as angioneurotic edema, serum sickness and anaphylaxis have been reported. Rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome, have been associated with LINCOCIN (lincomycin hcl) . If an allergic reaction to LINCOCIN (lincomycin hcl) occurs, discontinue the drug. Serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures, including oxygen, intravenous fluids, intravenous antihistamines, corticosteroids, pressor amines, and airway management, as clinically indicated.
Liver-Although no direct relationship of LINCOCIN (lincomycin hcl) to liver dysfunction has been established, jaundice and abnormal liver function tests (particularly elevations of serum transaminase) have been observed.
Special Senses-Tinnitus and vertigo have been reported occasionally.
Local Reactions-Patients have demonstrated excellent local tolerance to intramuscularly administered LINCOCIN (lincomycin hcl) . Reports of pain following injection have been infrequent. Intravenous administration of LINCOCIN (lincomycin hcl) in 250 to 500 mL of 5% dextrose injection or 0.9% sodium chloride injection produced no local irritation or phlebitis.
Read the Lincocin (lincomycin hcl) Side Effects Center for a complete guide to possible side effects »
Lincomycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used in caution in patients receiving such agents.
Last reviewed on RxList: 4/7/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Lincocin Information
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