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Lincocin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 8/6/2015

Lincocin (lincomycin hcl) is an antibiotic used to treat severe bacterial infections in people who cannot receive penicillin antibiotics. Common side effects of Lincocin include nausea, vomiting, swollen or painful tongue, vaginal itching or discharge, mild itching or skin rash, ringing in your ears, dizziness, or a spinning feeling.

Lincocin is given as an injection into a muscle, or through a needle placed into a vein, and is usually given every 12 to 24 hours. Dose depends on the severity of the patient's condition, the patient's age and weight. Lincocin may interact with erythromycin. Other drugs can interact with Lincocin. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Lincocin should be used only if prescribed. It may be harmful to a fetus. This medication can pass into breast milk and may harm a nursing baby. Consult your doctor before breast-feeding.

Our Lincocin (lincomycin hcl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Lincocin in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have any of these serious side effects:

  • diarrhea that is watery or bloody;
  • urinating less than usual or not at all;
  • fever, chills, body aches, flu symptoms;
  • severe blistering, peeling, and red skin rash;
  • feeling like you might pass out;
  • easy bruising or bleeding, unusual weakness; or
  • white patches or sores inside your mouth or on your lips.

Less serious side effects include:

  • nausea, vomiting;
  • swollen or painful tongue;
  • vaginal itching or discharge;
  • mild itching or skin rash;
  • ringing in your ears; or
  • dizziness, spinning feeling.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lincocin (Lincomycin Hcl)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Lincocin FDA Prescribing Information: Side Effects
(Adverse Reactions)


The following reactions have been reported with the use of lincomycin:


Glossitis, stomatitis, nausea, vomiting, antibacterial -associated diarrhea and colitis, and pruritus ani. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS).


Neutropenia, leukopenia, agranulocytosis and thrombocytopenic purpura have been reported. There have been rare reports of aplastic anemia and pancytopenia in which LINCOCIN could not be ruled out as the causative agent.

Hypersensitivity Reactions

Hypersensitivity reactions such as angioneurotic edema, serum sickness and anaphylaxis have been reported. Cases of erythema multiforme, some resembling Stevens-Johnson syndrome, have been associated with LINCOCIN (see WARNINGS).

Skin and Mucous Membranes

Skin rashes, urticaria and vaginitis and rare instances of exfoliative and vesiculobullous dermatitis have been reported.


Although no direct relationship of LINCOCIN to liver dysfunction has been established, jaundice and abnormal liver function tests (particularly elevations of serum transaminase) have been observed.


Although no direct relationship of lincomycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and/or proteinuria has been observed in rare instances.


After too rapid intravenous administration, rare instances of cardiopulmonary arrest and hypotension have been reported. (See DOSAGE AND ADMINISTRATION.)

Special Senses

Tinnitus and vertigo have been reported occasionally.

Local Reactions

Patients have demonstrated excellent local tolerance to intramuscularly administered LINCOCIN. Reports of pain following injection have been infrequent. Intravenous administration of LINCOCIN in 250 to 500 mL of 5% dextrose injection or 0.9% sodium chloride injection produced no local irritation or phlebitis.

Read the entire FDA prescribing information for Lincocin (Lincomycin Hcl)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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