"Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as the sensation of itch.
LINDANE LOTION, USP 1%
Lindane Lotion should only be used in patients who cannot tolerate or have failed first-line treatment with safer medications for the treatment of scabies. (See INDICATIONS)
Seizures and deaths have been reported following Lindane Lotion use with repeat or prolonged application, but also in rare cases following a single application used according to directions. Lindane Lotion should be used with caution for infants, children, the elderly, and individuals with other skin conditions (e.g., atopic dermatitis, psoriasis) and in those who weigh < 110 lbs (50 kg) as they may be at risk of serious neurotoxicity.
Lindane Lotion is contraindicated in premature infants and individuals with known uncontrolled seizure disorders.
Instruct patients on the proper use of Lindane Lotion, the amount to apply, how long to leave it on, and avoiding retreatment. Inform patients that itching occurs after the successful killing of scabies and is not necessarily an indication for retreatment with Lindane Lotion. (See DOSAGE AND ADMINISTRATION.)
Lindane Lotion, USP 1%, is an ectoparasiticide and ovicide. In addition to the active ingredient, lindane, it contains 2-amino-2-methyl- 1-propanol, carrageenan, cetyl alcohol, cocoa butter, glyceryl monostearate, methylparaben, propylene glycol, propylparaben, purified water, stearic acid and trolamine to form a lotion. The pH range is between 6.5 and 8.5. Lindane is the gamma isomer of 1,2,3,4,5,6- hexachlorocyclohexane having the following structural formula:
What are the possible side effects of lindane topical ()?
Stop using lindane topical and seek emergency medical attention if you experience an uncommon but serious side effect such as
- an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives);
- seizures; or
- uncontrollable body shaking.
Other less serious side effects may also occur. Talk to your doctor if you experience
- dizziness or drowsiness;
- itching, burning, dryness, or rash of the skin.
Side effects other than those listed here may also occur. Talk to your doctor about any...
What are the precautions when taking lindane lotion (Lindane Lotion)?
See also Warning section.
Before using lindane lotion, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: previous use of lindane in the past few months, other skin conditions (e.g., psoriasis, dermatitis), HIV infection, history of serious head injury, seizures, brain tumors, severe liver disease, alcohol abuse, sudden stopping of regular alcohol or sedative use.
This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are...
Last reviewed on RxList: 4/22/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Lindane Lotion Information
Lindane Lotion - User Reviews
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