"Spring break is on the way, or maybe summer vacation. Time to pack your swim suit, hit the beach, and perhaps indulge in a little harmless fun. What about getting a temporary tattoo to mark the occasion? Who could it hurt to get a temporary tatto"...
Lindane Lotion, USP 1%, is an ectoparasitcide and ovicide effective against Sarcoptes scabiei (scabies). Lindane exerts its parasiticidal action by being directly absorbed into the parasites and their ova. Feldmann and Maibach1 reported approximately 10% systemic absorption of a lindane acetone solution when applied to the forearm of human subjects and left in place for 24 hours. This vehicle was different from the approved product and the percutaneous penetration of lindane is dependent on the vehicle. Therefore, the clinical significance of these observations is unknown. Dale, et al2 reported a blood level of 290 ng/mL associated with convulsions following the accidental ingestion of a lindane-containing product. Ginsburg3 found the greatest peak blood level of 64 ng/mL, 6 hours after total body application of Lindane Lotion in 1 of 8 non-scabieic pediatric patients. The half-life in blood was determined to be approximately 18 hours.
Data available in the literature suggest that lindane has a rapid distribution phase followed by a longer β-elimination phase.1,2,3
1 Feldmann, R.J. and Maibach, H.I., Toxicol. Applied. Pharmacol.,28:126, 1974.
2. Dale, W.E., Curly, A. and Cueto, C. Life Sci 5:47,1966.
3. Ginsburg, C.M., et al., J. Pediatr.91:6, 998-1000,1977.
Last reviewed on RxList: 4/22/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Lindane Lotion Information
Lindane Lotion - User Reviews
Lindane Lotion User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Report Problems to the Food and Drug Administration
Find out what women really need.