"Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as the sensation of itch.
Lindane Lotion, USP 1%, is an ectoparasitcide and ovicide effective against Sarcoptes scabiei (scabies). Lindane exerts its parasiticidal action by being directly absorbed into the parasites and their ova. Feldmann and Maibach1 reported approximately 10% systemic absorption of a lindane acetone solution when applied to the forearm of human subjects and left in place for 24 hours. This vehicle was different from the approved product and the percutaneous penetration of lindane is dependent on the vehicle. Therefore, the clinical significance of these observations is unknown. Dale, et al2 reported a blood level of 290 ng/mL associated with convulsions following the accidental ingestion of a lindane-containing product. Ginsburg3 found the greatest peak blood level of 64 ng/mL, 6 hours after total body application of Lindane Lotion in 1 of 8 non-scabieic pediatric patients. The half-life in blood was determined to be approximately 18 hours.
Data available in the literature suggest that lindane has a rapid distribution phase followed by a longer β-elimination phase.1,2,3
1 Feldmann, R.J. and Maibach, H.I., Toxicol. Applied. Pharmacol.,28:126, 1974.
2. Dale, W.E., Curly, A. and Cueto, C. Life Sci 5:47,1966.
3. Ginsburg, C.M., et al., J. Pediatr.91:6, 998-1000,1977.
Last reviewed on RxList: 4/22/2008
This monograph has been modified to include the generic and brand name in many instances.
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