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Lindane Shampoo

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Lindane Shampoo

Lindane Shampoo

CLINICAL PHARMACOLOGY

Lindane exerts its parasiticidal action by being directly absorbed into the parasites and their ova. Feldmann and Maibach1 reported approximately 10% absorption of a lindane acetone solution applied to the forearm of human subjects and left in place for 24 hours. This vehicle was different from the approved product and the percutaneous penetration of lindane is dependent on the vehicle. Therefore, the clinical significance of these observations is unknown. Dale, et al2 reported a blood level of 290 ng/mL associated with convulsions following the accidental ingestion of a lindane-containing product. Ginsburg3 found a mean peak blood level of 28 ng/mL 6 hours after total body application of Lindane Lotion to scabietic infants and children. The half-life in blood was determined to be 18 hours.

Data available in the literature suggest that lindane has a rapid distribution phase followed by a longer β-elimination phase.1,2,3 There are no clinical dose ranging studies for Lindane Shampoo.

REFERENCES

1. Feldmann, R.J. and Maibach, H.I., Toxicol. Applied. Pharmacol., 28:126, 1974.

2. Dale, W.E., Curly, A. and Cueto, C. Life Sci 5:47, 1966.

3. Ginsburg, C.M., et al., J. Pediatr.91:6, 998-1000, 1977.

Last reviewed on RxList: 4/22/2008
This monograph has been modified to include the generic and brand name in many instances.

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