"The U.S. Food and Drug Administration today approved Viberzi (eluxadoline) and Xifaxan (rifaximin), two new treatments, manufactured by two different companies, for irritable bowel syndrome with diarrhea (IBS-D) in adult men and women.
There is limited experience with overdose of LINZESS. During the clinical development program of LINZESS, single doses of 2897 mcg were administered to 22 healthy volunteers; the safety profile in these subjects was consistent with that in the overall LINZESS-treated population, with diarrhea being the most commonly reported adverse reaction.
LINZESS is contraindicated in:
- Pediatric patients under 6 years of age [see WARNINGS AND PRECAUTIONS, Use In Specific Populations and Nonclinical Toxicology]
- Patients with known or suspected mechanical gastrointestinal obstruction
Last reviewed on RxList: 7/25/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Linzess Information
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