July 29, 2016
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Linzess Patient Information Including Side Effects

Brand Names: Linzess

Generic Name: linaclotide (Pronunciation: LIN a KLOE tide)

What is linaclotide (Linzess)?

Linaclotide works by increasing the secretion of chloride and water in the intestines, which can soften stools and stimulate bowel movements.

Linaclotide is used to treat chronic constipation, or chronic irritable bowel syndrome (IBS) in people who have had constipation as the main symptom.

Linaclotide may also be used for purposes not listed in this medication guide.

What are the possible side effects of linaclotide (Linzess)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using linaclotide and call your doctor at once if you have a serious side effect such as:

  • severe or ongoing diarrhea;
  • severe stomach pain; or
  • black, bloody, or tarry stools.

Other common side effects may include:

  • mild diarrhea;
  • mild stomach discomfort;
  • heartburn, vomiting, gas, bloating;
  • headache; or
  • cold symptoms such as stuffy nose, sneezing, sinus pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Linzess (linaclotide capsules) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about linaclotide (Linzess)?

You should not use linaclotide if you are allergic to it, or if you have a blockage in your stomach or intestines.

Do not give this medication to any child or teenager without the advice of a doctor.

Take linaclotide in the morning on an empty stomach, at least 30 minutes before your first meal. Do not crush, chew, break, or open a linaclotide capsule. Swallow it whole.

Stop using linaclotide and call your doctor at once if you have severe or ongoing diarrhea, severe stomach pain, or black, bloody, or tarry stools.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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