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Lioresal Intrathecal

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Lioresal Intrathecal

LIORESAL® Intrathecal
(baclofen) Injection 0.05 mg/mL, 0.5 mg/mL and 2 mg/mL

For intrathecal injection and infusion only

DRUG DESCRIPTION

Drug Substance

LIORESAL (baclofen) Structural Formula Illustration

Baclofen

Chemical Name: 4-amino-3-(p-chlorophenyl) butyric acid

Molecular Formula: C10H12ClNO2

Molecular Weight: 213.67

Description: White to off-white, odorless or practically odorless crystalline powder.

Solubility: Slightly soluble in water, very slightly soluble in methanol and insoluble in chloroform.

pKa: pKa, 1 = 3.87 (carboxyl group) and pKa, 2 = 9.62 (amino group) in water at 20OC.

Composition

The contents of each sterile ampoule are described in the following table.

Dosage mg/mL Total Volume mL Medicinal ingredient Non-medicinal ingredients
Baclofen/mg Sodium chloride/mg Water for injection
0.05 1 0.05 9 up to 1 mL
0.5 20 10 180 up to 20 mL
2 5 10 45 up to 5 mL

Last reviewed on RxList: 1/10/2014
This monograph has been modified to include the generic and brand name in many instances.

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