"Nov. 2, 2012 -- Safety steps taken in the wake of the fungal meningitis outbreak have worsened drug shortages, raising questions about whether the U.S. must choose between the safety and the availability of crucial medicines.
(baclofen) Injection 0.05 mg/mL, 0.5 mg/mL and 2 mg/mL
For intrathecal injection and infusion only
Chemical Name: 4-amino-3-(p-chlorophenyl) butyric acid
Molecular Formula: C10H12ClNO2
Molecular Weight: 213.67
Description: White to off-white, odorless or practically odorless crystalline powder.
Solubility: Slightly soluble in water, very slightly soluble in methanol and insoluble in chloroform.
pKa: pKa, 1 = 3.87 (carboxyl group) and pKa, 2 = 9.62 (amino group) in water at 20OC.
The contents of each sterile ampoule are described in the following table.
|Dosage mg/mL||Total Volume mL||Medicinal ingredient||Non-medicinal ingredients|
|Baclofen/mg||Sodium chloride/mg||Water for injection|
|0.05||1||0.05||9||up to 1 mL|
|0.5||20||10||180||up to 20 mL|
|2||5||10||45||up to 5 mL|
Last reviewed on RxList: 1/10/2014
This monograph has been modified to include the generic and brand name in many instances.
Additional Lioresal Intrathecal Information
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