Lioresal Intrathecal (Baclofen Injection) Drug Information: Overdosage and Contraindications

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May 27, 2012

Lioresal Intrathecal

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Lioresal Intrathecal

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OVERDOSE

Special attention must be given to recognizing the signs and symptoms of overdosage, especially during the initial screening and dose- titration phase of treatment, but also during re-introduction of LIORESAL INTRATHECAL (baclofen injection) after a period of interruption in therapy.

Symptoms of LIORESAL INTRATHECAL (baclofen injection) Overdose

Drowsiness, lightheadedness, dizziness, somnolence, respiratory depression, hypothermia, seizures, rostral progression of hypotonia and loss of con- sciousness progressing to coma of up to 72 hr. duration. In most cases reported, coma was reversible without sequelae after drug was discontinued. Symptoms of LIORESAL INTRATHECAL (baclofen injection) overdose were reported in a sensitive adult patient after receiving a 25 mcg intrathecal bolus.

Treatment Suggestions for Overdose

There is no specific antidote for treating overdoses of LIORESAL INTRATHECAL (baclofen injection); however, the following steps should ordinarily be undertaken:

Residual LIORESAL INTRATHECAL (baclofen injection) solution should be removed from the pump as soon as possible.
Patients with respiratory depression should be intubated if necessary, until the drug is eliminated.

If lumbar puncture is not contraindicated, consideration should be given to withdrawing 30- 40 ml of CSF to reduce CSF baclofen concentration.

CONTRAINDICATIONS

Hypersensitivity to baclofen. LIORESAL INTRATHECAL (baclofen injection) is not recommended for intravenous, intramuscular, subcutaneous or epidural administration.

Last reviewed on RxList: 5/13/2011
This monograph has been modified to include the generic and brand name in many instances.