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Symptoms And Treatment Of Overdosage
For management of a suspected drug overdose, contact your regional Poison Control Centre for the most current information.
Special attention must be given to recognizing the signs and symptoms of overdosage at all times, especially during the initial “screening” and “dose titration” phase of treatment and also during reintroduction of LIORESAL Intrathecal (baclofen injection) after a period of interruption of therapy.
Signs of overdose may appear suddenly or insidiously.
Less sudden and/or less severe forms of overdose may present with signs of drowsiness, lightheadedness, dizziness, somnolence, seizures, loss of consciousness, hypothermia, excessive salivation, nausea and/or vomiting and cephalad progression of hypotonia. Respiratory depression, apnea, and coma result from serious overdosage.
Serious overdose may occur, for example, by inadvertent delivery of catheter contents during catheter patency/position analysis. Errors in programming, excessively rapid dose increases, and concomitant treatment with oral baclofen are other possible causes of overdosage. Possible pump malfunction should also be investigated.
Symptoms of severe LIORESAL Intrathecal overdose (coma) were reported in a sensitive adult patient after receiving a 25 μg intrathecal bolus dose.
There is no specific antidote for treating overdoses of intrathecal baclofen, however, the following steps should generally be undertaken:
- Residual LIORESAL solution should be removed from the pump as soon as possible.
- Patients with respiratory depression should be intubated if necessary, until the drug is eliminated.
Institute measures to support cardiovascular function.
In the event of convulsions, administer diazepam I.V. with caution.
Known or suspected hypersensitivity to baclofen or to any of the excipients.
LIORESAL Intrathecal should not be administered by intravenous, intramuscular, subcutaneous or epidural routes.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 1/10/2014
Additional Lioresal Intrathecal Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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