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Liposyn

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Liposyn II

Liposyn® II
(Intravenous Fat Emulsion)

Liposyn II

DRUG DESCRIPTION

Liposyn II (Intravenous Fat Emulsion) is a sterile, nonpyrogenic fat emulsion for intravenous administration. It is supplied in both a 10% and 20% concentration.

Liposyn II (intravenous fat emulsion) 10% contains 5% safflower oil, 5% soybean oil, up to 1.2% egg phosphatides added as an emulsifier and 2.5% glycerin in water for injection. May contain sodium hydroxide for pH adjustment. pH 8.0 (6.0 — 9.0). Liposyn II (intravenous fat emulsion) 10% has an osmolarity of 276 mOsmol/liter (actual). The total caloric value of Liposyn II (intravenous fat emulsion) 10% including fat, phospholipid and glycerol is 1.1 kcal/mL. Of this total, approximately 0.6 kcal/mL is supplied by linoleic acid.

Liposyn II (intravenous fat emulsion) 20% contains 10% safflower oil, 10% soybean oil, 1.2% egg phosphatides and 2.5% glycerin in water for injection. May contain sodium hydroxide for pH adjustment. pH 8.3 (6.0 _ 9.0). Liposyn II (intravenous fat emulsion) 20% has an osmolarity of 258 mOsmol/liter (actual). The total caloric value of Liposyn II (intravenous fat emulsion) 20% including fat, phospholipid and glycerol is 2 kcal/mL. Of this total, approximately 1.2 kcal/mL are supplied by linoleic acid.

Both Liposyn II (intravenous fat emulsion) 10% and Liposyn II (intravenous fat emulsion) 20% contain emulsified fat particles of approximately 0.4 micron in diameter, similar to naturally occurring chylomicrons.

Safflower oil and Soybean Oil, USP are mixtures of neutral triglycerides with the following structure:

Safflower oil Structural Formula Illustration

Soybean Oil Structural Formula Illustration

are saturated and unsaturated fatty acid residues. The major component fatty acids of the 50/50 safflower/soybean oil mixture are approximately 65.8% linoleic, 17.7% oleic, 8.8% palmitic, 3.4% stearic, and 4.2% linolenic acid. These fatty acids have the following chemical and structural formulas:

Major component fatty acids Structural Formula Illustration

Egg phosphatides, purified, are primarily a mixture of naturally occurring phospholipids which are isolated from the egg yolk. These phospholipids have the following general structure:

Egg phosphatides - Structural Formula Illustration

Egg phosphatides - Structural Formula Illustration

are the same saturated and unsaturated fatty acid residues that abound in neutral fats. R3 is primarily either the choline [HOCH2CH2N(CH3)3OH] ester or ethanolamine (HOCH2CH2NH2) ester of phosphoric acid (H3PO4).

Glycerin, USP is chemically designated C3H803 and is a clear colorless, hygroscopic syrupy liquid. It has the following structural formula:

Glycerin Structural Formula Illustration

What are the precautions when taking intravenous fat emulsion (Liposyn II)?

See also Warning section.

Before receiving the fat emulsion, tell your doctor or pharmacist if you are allergic to it; or to eggs, soybean oil, or safflower oil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This product should not be used if you have certain medical conditions. Before using this product, consult your doctor or pharmacist if you have: high fat (lipid) levels in the blood.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe liver disease, kidney disease, lung disease, anemia, blood clotting disorder.

Kidney function declines as you grow older. This medication...

Read All Potential Precautions of Liposyn II »

Last reviewed on RxList: 1/30/2009
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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