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Liposyn III

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Liposyn III

Liposyn® III
(Intravenous Fat Emulsion)

DRUG DESCRIPTION

Liposyn III (Intravenous Fat Emulsion) is a sterile, nonpyrogenic fat emulsion for intravenous administration. It is supplied in both a 10% and 20% concentration.

Liposyn III (intravenous fat emulsion) 10% contains 10% soybean oil, up to 1.2% egg phosphatides added as an emulsifier and 2.5% glycerin in water for injection. Sodium hydroxide has been added for pH adjustment. pH 8.3 (6.0 to 9.0). Liposyn III (intravenous fat emulsion) 10% has an osmolarity of 284 mOsmol/L (approx.) and a specific gravity of 0.995. The total caloric value of Liposyn III (intravenous fat emulsion) 10% including fat, phospholipid and glycerol is 1.1 kcal/mL. Of this total, approximately 0.5 kcal/mL is supplied by linoleic acid.

Liposyn III (intravenous fat emulsion) 20% contains 20% soybean oil, 1.2% egg phosphatides and 2.5% glycerin in water for injection. Sodium hydroxide has been added for pH adjustment. pH 8.3 (6.0 to 9.0). Liposyn III (intravenous fat emulsion) 20% has an osmolarity of 292 mOsmol/L (approx.) and a specific gravity of 0.988. The total caloric value of Liposyn III (intravenous fat emulsion) 20% including fat, phospholipid and glycerol is 2.0 kcal/mL. Of this total, approximately 1.0 kcal/mL is supplied by linoleic acid.

Both Liposyn III (intravenous fat emulsion) 10% and Liposyn III (intravenous fat emulsion) 20% contain emulsified fat particles of approximately 0.4 micron in diameter, similar to naturally occurring chylomicrons.

Soybean Oil, USP is a mixture of neutral triglycerides with the following structure:

Soybean Oil - Structural Formula Illustration

Saturated and unsaturated fatty acid residues - Illustration

are saturated and unsaturated fatty acid residues. The major component fatty acids are approximately 54.5% linoleic, 22.4% oleic, 10.5% palmitic, 4.2% stearic, and 8.3% linolenic acid. These fatty acids have the following chemical and structural formulas:

Liposyn® III 
  INTRAVENOUS FAT EMULSION  Structural Formula Illustration

Egg phosphatides, purified, are primarily a mixture of naturally occurring phospholipids which are isolated from the egg yolk. These phospholipids have the following general structure:

P- Structural Formula Illustration

Saturated and unsaturated fatty acid residues - Illustration

are the same saturated and unsaturated fatty acid residues that abound in neutral fats. R3 is primarily either the choline [HOCH2CH2N(CH3)30H] ester or ethanolamine (HOCH2CH2NH2) ester of phosphoric acid (H3PO4).

Glycerin, USP is chemically designated C3H803 and is a clear, colorless, hygroscopic syrupy liquid. It has the following structural formula:

Glycerin Structural formula Illustration

What are the precautions when taking intravenous fat emulsion (Liposyn III)?

See also Warning section.

Before receiving the fat emulsion, tell your doctor or pharmacist if you are allergic to it; or to eggs, safflower oil, or soy/peanut found in some brands; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This product should not be used if you have certain medical conditions. Before using this product, consult your doctor or pharmacist if you have: high fat (lipid) levels in the blood.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe liver disease, kidney disease, lung disease, anemia, blood clotting disorder.

Kidney function declines as you grow...

Read All Potential Precautions of Liposyn III »

Last reviewed on RxList: 2/2/2009
This monograph has been modified to include the generic and brand name in many instances.

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