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Liposyn III

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Liposyn III

Indications
Dosage
How Supplied

INDICATIONS

Liposyn III (intravenous fat emulsion) is indicated as a source of calories for patients requiring parenteral nutrition. Where such nutrition is required for extended periods of time (more than 5 days), Liposyn III (intravenous fat emulsion) is also indicated as a source of essential fatty acids to prevent or reverse biochemical changes in fatty acid composition of plasma lipids (elevated triene/tetraene ratio) and the clinical manifestations of EFAD.

DOSAGE AND ADMINISTRATION

Liposyn III (intravenous fat emulsion) should be administered as part of an intravenous total nutrition program via peripheral vein or central venous catheter.

Adult Patients

Liposyn III (intravenous fat emulsion) can provide up to 60% of daily calories at a dose not to exceed 3 g/kg of body weight per day. The other 40% should be provided by carbohydrate and amino acids.

For the prevention of essential fatty acid deficiency, the recommended daily requirement is approximately 4% of the caloric intake as linoleate. In most adult patients, this can be supplied as 500 mL of Liposyn III (intravenous fat emulsion) 10% or 250 mL of Liposyn III (intravenous fat emulsion) 20% administered three times weekly.

The initial infusion rate for the first 15 minutes should be 1.0 mL/minute for Liposyn III (intravenous fat emulsion) 10% and 0.5 mL/minute for Liposyn III (intravenous fat emulsion) 20%. If no adverse effects are observed during this initial infusion, the rate can be increased to allow no more than 500 mL of Liposyn III (intravenous fat emulsion) 10% or 250 mL of Liposyn III (intravenous fat emulsion) 20% to be given over a period of four to six hours.

Pediatric Patients

Liposyn III (intravenous fat emulsion) can provide up to 60% of daily calories at a dose not to exceed 4 g/kg of body weight per day. The other 40% should be provided by carbohydrate and amino acids.

For the prevention of essential fatty acid deficiency, the recommended daily requirement is approximately 4% of the caloric intake as linoleate. The daily dosage of Liposyn III (intravenous fat emulsion) ranges from 7.5 mL to 15 mL per kilogram for the 10% emulsion and 3.8 mL to 7.5 mL per kilogram for the 20% emulsion, depending upon the size and maturity of the patient.

The infusion should be started at a rate of 0.1 mL/minute for the first 15 minutes. If no adverse effects are observed during this initial infusion, the rate can be increased to allow no more than 100 mL of Liposyn III (intravenous fat emulsion) 10% or 50 mL of Liposyn III (intravenous fat emulsion) 20% per hour.

Administration

See CONTRAINDICATIONS regarding mixing this emulsion with other I.V. fluids or additives.

Liposyn III (intravenous fat emulsion) can be infused into the same central or peripheral vein as the carbohydrate/amino acid solutions by means of a short Y-connector near the infusion site. This allows for mixing of the solutions immediately before entering the vein or for alternation of each solution. Flow rates of each solution should be controlled separately by infusion pumps, if these are used. Fat emulsion may also be infused through a separate peripheral site. If desired, heparin may be added to Liposyn III (intravenous fat emulsion) at a concentration of 1 to 2 units per mL prior to administration. Conventional administration sets contain polyvinyl chloride (PVC) components that have DEHP (diethylhexyl phthalate) as a plasticizer. Fat-containing fluids such as Liposyn extract DEHP from this PVC component, and it may be advisable to consider infusion of Liposyn III (intravenous fat emulsion) through a non-DEHP administration set. Filters should not be used for administration of the emulsion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

HOW SUPPLIED

Liposyn III (intravenous fat emulsion) 10% and 20% is a white to slightly off-white emulsion with no evidence of oiling out of the emulsion.

Liposyn III (intravenous fat emulsion) 10% (List No. 9790) is supplied in 200, 250 and 500 mL single-dose containers. Liposyn III (intravenous fat emulsion) 20% (List No. 9791) is supplied in 200, 250 and 500 mL single-dose containers.

Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing.

Revised: September, 2005. Hospira, Inc., Lake Forest, IL 60045 USA. FDA rev date: 3/24/2003

Last reviewed on RxList: 2/2/2009
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
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