August 24, 2016
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Liposyn II

Liposyn Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 3/21/2016

Liposyn II (intravenous fat emulsion) is made of 20% soybean oil and used to provide calories to patients who are getting their nutrition through an injection into a vein. Liposyn II is also used to provide essential fatty acids to people who do not have enough of it, and it helps to prevent or reverse the signs of fatty acid deficiency (e.g., scaly skin, poor growth, poor wound healing). Liposyn II is available in generic form. Common side effects of Liposyn II include:

  • headache
  • dizziness
  • flushing
  • drowsiness
  • nausea
  • vomiting, or
  • sweating

The initial rate of infusion of Liposyn II in adults is a dose of 1 mL/minute Liposyn II 10% and 0.5 mL/minute for Liposyn II 20%. If no adverse effects are observed during this initial infusion, the rate can be increased to allow no more than 500 mL of Liposyn II 10% or 250 mL of Liposyn II 20% to be given over a period of 4 to 6 hours. Liposyn II may interact with other drugs. Tell your doctor all medications and supplements you take. Liposyn II should be used during pregnancy only if clearly needed. It is not known if Liposyn II passes into breast milk. Consult your doctor before breastfeeding.

Our Liposyn II (intravenous fat emulsion) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Liposyn Overview - Patient Information: Side Effects

SIDE EFFECTS: Headache, dizziness, flushing, drowsiness, nausea, vomiting, or sweating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: signs of infection (e.g., fever, persistent sore throat), pain/swelling/redness at injection site, pain/swelling/redness of arms/legs, bluish skin, sudden weight gain, shortness of breath, back/chest pain.

Tell your doctor immediately if any of these rare but very serious side effects occur: mental/mood changes, bone pain, muscle weakness, yellowing skin/eyes, dark urine, easy bruising/bleeding, severe stomach/abdominal pain, trouble breathing.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Liposyn (Intravenous Fat Emulsion)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Liposyn FDA Prescribing Information: Side Effects
(Adverse Reactions)


Sepsis due to contamination of administration equipment and thrombophlebitis due to vein irritation from concurrently administered hypertonic solutions have been encountered. These are attributable to I.V. therapy in general or to the type of infusion administered.

Adverse reactions directly related to fat emulsions are of two types: (1) immediate (acute) and (2) long term (chronic). In studies of lipid products in general, the following immediate reactions have been noted: Allergic reactions, hyperlipemia, dyspnea, cyanosis, flushing, dizziness, headache, sleepiness, nausea, vomiting, hyperthermia, sweating, chest and back pain, thrombocytopenia (rarely in neonates), hypercoagulability and transient increases in liver enzymes.

The following reactions have been noted with long-term therapy with lipid infusions in general: Hepatomegaly, jaundice due to central lobular cholestasis, splenomegaly, thrombocytopenia, leucopenia, transient increases in liver function tests, overloading syndrome and deposition of brown pigment (''fat pigment'') in the reticuloendothelial tissue of the liver. The significance of this last occurrence and its cause are unknown.

Read the entire FDA prescribing information for Liposyn (Intravenous Fat Emulsion)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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