July 25, 2016
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Liver (Anatomy and Function) (cont.)

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Liver disease causes (medications, toxins, genetics, cancer, and others)

Medications or drug induced liver inflammation

Liver inflammation is a relatively common side effect of medications. Some commonly prescribed medications include the following:

  • acetaminophen over the counter (Tylenol, Panadol) but also in prescription pain medications (hydrocodone/acetaminophen (Lortab, Vicodin, Norco)
  • Statins (medications used to control elevated blood cholesterol levels)
  • Antibiotics (amoxiciilin-clavulinic acid [Augmentin, Augmentin XR], nitrofurantoin [Macrodantin, Furadantin, Macrobid], tetracycline, isoniazid)
  • methotrexate (Trexall, Rheumatrex)
  • disulfiram (Antabusel)
  • Herbal remedies, for example, kava kava, mahuang, comfrey

Toxins

  • Poisonous mushrooms may damage the liver and cause liver failure.
  • Alcohol in large doses can be toxic for the liver and damages the liver over time.
  • Aflatoxins produced by certain fungi are toxic to the liver
  • Industrial chemicals may be toxins that affect the liver, such as arsenic and carbon tetrachloride

Genetic disorders

Genetic disorders can affect the liver, examples include the following:

  • Hemochromatosis with abnormal iron storage
  • Wilson's Disease with abnormal copper storage
  • Gilbert's Disease with abnormal bilirubin metabolism

Cancer

  • Primary liver cancers arise directly from cells within the liver.
  • Metastatic liver disease describes cancer that arises from another organ and invades the liver

Abnormalities of bile flow from the liver

Abnormalities of bile flow from the liver may lead to liver inflammation, for example:

Decrease in blood flow draining from the liver

Decrease in blood flow draining out of the liver may cause the liver to become congested and inflamed, two examples include:

  • Congestive heart failure (CHF) is a condition in which the heart is not strong enough to pump all of the blood it receives, and that blood can back up into the liver.
  • Budd Chiari syndrome is a disease in which blood clots form in the hepatic veins, preventing blood from leaving the liver.
Medically Reviewed by a Doctor on 4/5/2016

Source: MedicineNet.com
http://www.medicinenet.com/liver_anatomy_and_function/article.htm

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