Liver Blood Tests (cont.)
Charles Patrick Davis, MD, PhD
Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.
William C. Shiel Jr., MD, FACP, FACR
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
In this Article
- What are the basic functions of the liver?
- What are common liver blood tests?
- What are the aminotransferases?
- Normally, where are the aminotransferases?
- What are normal levels of AST and ALT?
- What do high (elevated) liver tests (AST and ALT) mean?
- Do AST and ALT test results indicate liver function?
- What blood tests are done to detect liver function?
- What are some common reasons for abnormal liver tests?
- What medications can cause increased liver enzyme tests (abnormal aminotransferase levels)?
- What conditions can cause very high aminotransferase levels?
- What are some of the less common causes of elevated liver blood tests?
- How are healthy people evaluated for mild to moderate rises in aminotransferase levels?
- How about monitoring liver blood tests?
- What about the other liver enzymes?
- Hepatitis Slideshow Pictures
- Take the Alcohol Quiz
- Alcohol Abuse Slideshow Pictures
What are the aminotransferases?
The aminotransferases catalyze chemical reactions in which an amino group from one amino acid (amino acids are building blocks of proteins) is transferred from a donor molecule to a recipient molecule, hence, the names "aminotransferases."
Medical terms can sometimes be confusing, as is the case with these enzymes because they have interchangeable names that commonly appear in both medical and non-medical articles. For example:
- Another name for aminotransferase is transaminase.
- The enzyme aspartate aminotransferase (AST) is also known as serum glutamic oxaloacetic transaminase (SGOT).
- Alanine aminotransferase (ALT) is also known as serum glutamic pyruvic transaminase (SGPT).
To put matters briefly, AST = SGOT and ALT = SGPT.
Normally, where are the aminotransferases?
AST (SGOT) is normally found in a variety of tissues including liver, heart, muscle, kidney, and brain. It is released into the serum when any one of these tissues is damaged. For example, AST level in serum is elevated in heart attacks or with muscle injury. It is therefore, not a highly specific indicator of liver injury as its elevation can occur as a result of other injured tissues.
ALT (SGPT) is, by contrast, normally found largely in the liver. This is not to say that it is exclusively located in the liver, but that is where it is most concentrated. It is released into the bloodstream as the result of liver injury. Thus, it serves as a fairly specific indicator of liver status.
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