October 4, 2015

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Liver Blood Tests

Normally, where are the aminotransferases?

AST (SGOT) is normally found in a variety of tissues including liver, heart, muscle, kidney, and the brain. It is released into the serum when any one of these tissues is damaged. For example, AST level in serum is elevated in heart attacks or with muscle injury. It is therefore, not a highly specific indicator of liver injury as its elevation can occur as a result of other injured tissues.

ALT (SGPT) is, by contrast, normally found largely in the liver. This is not to say that it is exclusively located in the liver, but that is where it is most concentrated. It is released into the bloodstream as the result of liver injury. Thus, it serves as a fairly specific indicator of liver status.

What are normal levels of AST and ALT?

  • The normal range of values for AST (SGOT) is about 5 to 40 units per liter of serum (the liquid part of the blood).
  • The normal range of values for ALT (SGPT) is about 7 to 56 units per liter of serum.

However, the ranges of AST and ALT numbers may differ slightly depending on the technique and protocols used by different laboratories worldwide. However, normal reference ranges are routinely provided by each laboratory and printed with each patient's individual report. Continue Reading

Reviewed on 4/30/2015