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Lo Loestrin FE

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Lo Loestrin FE

LO LOESTRIN FE (norethindrone acetate and ethinyl estradiol, ethinyl estradiol tablets)
(norethindrone acetate and ethinyl estradiol, ethinyl estradiol and ferrous fumarate) Tablets

WARNING: CIGARETTE SMOKING AND SERIOUS

CARDIOVASCULAR EVENTS

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs should not be used by women who are over 35 years of age and smoke. [See CONTRAINDICATIONS.]

DRUG DESCRIPTION

Lo Loestrin Fe (norethindrone acetate and ethinyl estradiol, ethinyl estradiol tablets) (norethindrone acetate and ethinyl estradiol tablets, ethinyl estradiol tablets and ferrous fumarate tablets) provides an oral contraceptive regimen consisting of 24 blue active tablets and 2 white active tablets that contain the active ingredients specified for each tablet below, followed by 2 non-hormonal placebo tablets:

  • 24 blue, round tablets each containing 1 mg norethindrone acetate and 10 meg ethinyl estradiol
  • 2 white, hexagonal tablets each containing 10 meg ethinyl estradiol
  • 2 brown, round tablets each containing 75 mg ferrous fumarate

Each blue tablet also contains the inactive ingredients mannitol, microcrystalline cellulose, FD&C Blue No. 1 Aluminum Lake, sodium starch glycolate, magnesium stearate, povidone, vitamin E and lactose monohydrate.

Each white tablet also contains the inactive ingredients mannitol, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, povidone, vitamin E and lactose monohydrate.

Each brown tablet contains ferrous fumarate, mannitol, povidone, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, sucralose and spearmint flavor. The ferrous fumarate tablets do not serve any therapeutic purpose. Ferrous fumarate tablets are not USP for dissolution and assay.

The empirical formula of ethinyl estradiol is C20H24O2 and the structural formula is:

Ethinyl estradiol Structural Formula Illustration

The chemical name of ethinyl estradiol is [19-Norpregna-l,3,5(10)-trien-20-yne-3,17-diol, (17α)-].

The empirical formula of norethindrone acetate is C22H28O3 and the structural formula is:

Norethindrone acetate Structural Formula Illustration

The chemical name of norethindrone acetate is [19-Norpregn-4-en-20-yn-3-one, 17-(acetyloxy)-, (17α)-].

What are the precautions when taking norethindrone acetate and ethinyl estradiol, ethinyl estradiol tablets (Lo Loestrin FE)?

See also Warning section.

Before using this medication, tell your doctor or pharmacist if you are allergic to ethinyl estradiol, norethindrone, or ferrous fumarate; or to other estrogens, progestins, or iron products; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood clots (for example, in the legs, eyes, lungs), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, abnormal breast exam, cancer (especially endometrial or breast cancer), high cholesterol or triglyceride (blood fat) levels, depression,...

Read All Potential Precautions of Lo Loestrin FE »

Last reviewed on RxList: 11/30/2010
This monograph has been modified to include the generic and brand name in many instances.

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