May 27, 2017
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Locoid Lipocream

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Locoid Lipocream

Locoid Lipocream
(hydrocortisone butyrate) Cream, 0.1%

For topical use only


Locoid Lipocream contains hydrocortisone butyrate, a non-fluorinated hydrocortisone ester [Pregn-4-ene-3, 20-dione, 11, 21-dihydroxy-17- [(1-oxobutyl) oxy (11β)-] for topical dermatologic use.

Chemically, hydrocortisone butyrate is C25H36O6. It has the following structural formula:

Locoid Lipocream (hydrocortisone butyrate)  Structural Formula Illustration

Hydrocortisone butyrate is a white to practically white powder with a molecular weight of 432.56. It is practically insoluble in water, slightly soluble in ether, soluble in methanol, in alcohol, and in acetone, and freely soluble in chloroform.

Each gram of Locoid Lipocream (hydrocortisone butyrate) contains 1 mg hydrocortisone butyrate in a hydrophilic base consisting of cetostearyl alcohol, ceteth-20, mineral oil, white petrolatum, citric acid, sodium citrate, propylparaben and butylparaben (preservatives) and water.

What are the possible side effects of hydrocortisone topical?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using hydrocortisone topical and call your doctor at once if you have any of these serious side effects:

  • blurred vision, or seeing halos around lights;
  • uneven heartbeats;
  • sleep problems (insomnia);
  • weight gain, puffiness in your face; or
  • feeling tired.

Less serious side effects may include:

  • skin redness, burning, itching, or peeling;
  • thinning...

Read All Potential Side Effects and See Pictures of Locoid Lipocream »

What are the precautions when taking hydrocortisone butyrate (Locoid Lipocream)?

Before using hydrocortisone butyrate, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e.g., prednisone, triamcinolone); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: poor blood circulation, diabetes, immune system problems.

Do not use if there is an infection or sore in the area to be treated.

Rarely, using corticosteroid medications for a long time or over large areas of skin can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency...

Read All Potential Precautions of Locoid Lipocream »

Last reviewed on RxList: 2/17/2017
This monograph has been modified to include the generic and brand name in many instances.

Locoid Lipocream - User Reviews

Locoid Lipocream User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Locoid Lipocream sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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