"The US Food and Drug Administration (FDA) has approved an extended-release capsule formulation of carbidopa-levodopa (Rytary, IPX066, Impax Pharmaceuticals) for the treatment of Parkinson's disease (PD), postencephalitic parkinsonism, an"...
When LODOSYN (Carbidopa) is to be given to carbidopa-naive patients who are beingtreated with levodopa, the two drugs should be given at the same time, starting with nomore than 20 to 25% of the previous daily dosage of levodopa when given withoutLODOSYN (Carbidopa). At least twelve hours should elapse between the last dose oflevodopa and initiation of therapy with LODOSYN (Carbidopa) and levodopa. See the WARNINGS and DOSAGE AND ADMINISTRATION sections before initiatingtherapy.
Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as (–)-L-α-hydrazino-α-methyl-β-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is C10H14N2O4•H2O and its structural formula is:
LODOSYN (Carbidopa) tablets contain 25 mg of carbidopa. Inactive ingredients are cellulose,FD&C Yellow 6, magnesium stearate and starch.
Tablet content is expressed in terms of anhydrous carbidopa which has a molecular weight of 226.3.
What are the possible side effects of carbidopa (Lodosyn)?
Carbidopa alone is not associated with side effects. The following side effects are generally associated with carbidopa and levodopa therapy.
If you experience any of the following serious side effects, stop taking carbidopa and levodopa and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- uncontrolled movements of a part of the body;
- persistent nausea, vomiting, or diarrhea;
- an irregular heartbeat or...
What are the precautions when taking carbidopa (Lodosyn)?
Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (narrow-angle glaucoma).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e.g., asthma, emphysema), certain eye problem (wide-angle glaucoma), heart or blood vessel problems (e.g., arrhythmias, heart attack, angina), kidney disease, liver disease, mental/mood disorders (e.g.,...
Last reviewed on RxList: 3/10/2014
This monograph has been modified to include the generic and brand name in many instances.
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