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Lodosyn Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Lodosyn (carbidopa) is an inhibitor of aromatic amino acid decarboxylation used with levodopa to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. Lodosyn and levodopa are also used to treat the same muscular conditions when caused by drugs such as chlorpromazine, fluphenazine, perphenazine, and others. Levodopa is turned into dopamine in the body. Lodosyn (carbidopa) is used with levodopa to prevent the breakdown (metabolism) of levodopa before it can reach the brain and take effect. Side effects with Lodosyn are rare and usually occur due to the effect of levodopa or other drugs used along with this medication. Side effects of Lodosyn and levodopa may include:
- loss of appetite
- trouble sleeping (insomnia)
- unusual dreams or nightmares
- dry mouth
- blurred vision
- hand tremor
- muscle twitches
- darkening of urine
- sweat, or
Most patients respond to a 1:10 proportion of Lodosyn and levodopa, provided the daily dosage of Lodosyn is 70 mg or more a day. The maximum daily dosage of Lodosyn should not exceed 200 mg. Lododyn may interact with monoamine oxidase inhibitors (MAOIs), antacids, medicines to treat high blood pressure, medicines to treat seizures, papaverine, pyridoxine or vitamin B6, antidepressants, or medicines used to treat psychiatric conditions. Tell your doctor all medications and supplements you use. Lodosyn should be used only when prescribed during pregnancy. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.
Our Lodosyn (carbidopa) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Lodosyn in Detail - Patient Information: Side Effects
Carbidopa alone is not associated with side effects. The following side effects are generally associated with carbidopa and levodopa therapy.
If you experience any of the following serious side effects, stop taking carbidopa and levodopa and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- uncontrolled movements of a part of the body;
- persistent nausea, vomiting, or diarrhea;
- an irregular heartbeat or fluttering in your chest;
- unusual changes in mood or behavior; or
- depression or suicidal thoughts.
Other, less serious side effects may be more likely to occur. Continue to take carbidopa and levodopa and talk to your doctor if you experience
- mild nausea, vomiting, or decreased appetite;
- constipation, dry mouth, or blurred vision;
- hand tremor;
- muscle twitches;
- dizziness or drowsiness;
- insomnia, confusion, or nightmares;
- agitation or anxiety;
- darkening of urine or sweat; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Lodosyn (Carbidopa)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Lodosyn Overview - Patient Information: Side Effects
Tell your doctor immediately if you notice worsening involuntary muscle movements/spasms, greatly increased eye blinking/twitching, or mental/mood changes (e.g., confusion, depression, hallucinations, thoughts of suicide). Your doctor may decide to lower your levodopa dose.
Dizziness, nausea, and vomiting may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Some people taking carbidopa have fallen asleep suddenly during their usual daily activities (such as talking on the phone, driving). In some cases, sleep occurred without any feelings of drowsiness beforehand. This sleep effect may occur anytime during treatment with carbidopa, including up to 1 year after starting the medication. If you experience increased sleepiness or fall asleep during the day, do not drive or take part in other possibly dangerous activities until you have discussed this effect with your doctor. Your risk of this sleep effect is increased by using alcohol or other medications that can make you drowsy. See also Precautions section.
Tell your doctor immediately if any of these unlikely but serious side effects occur: fainting, unusual strong urges (such as increased gambling, increased sexual urges).
Tell your doctor immediately if any of these rare but very serious side effects occur: easy bleeding/bruising, signs of infection (e.g., fever, persistent sore throat), tingling of the hands/feet, vision changes (e.g., blurred/double vision).
Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, seizures, vomit that looks like coffee grounds, black/tarry stools.
Abruptly stopping or reducing the dose of this medication may rarely cause a serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, unusual muscle stiffness, severe confusion, sweating, fast/irregular heartbeat, rapid breathing.
For males, in the very unlikely event you have a painful or prolonged erection (lasting more than 4 hours), stop using this drug and seek immediate medical attention or permanent problems could occur.
A very serious allergic reaction is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Lodosyn (Carbidopa)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Lodosyn FDA Prescribing Information: Side Effects
Carbidopa has not been demonstrated to have any overt pharmacodynamic actions in the recommended doses. The only adverse reactions that have been observed have been with concomitant use of carbidopa with other drugs such as levodopa, and with carbidopalevodopa combination products.
When LODOSYN is administered concomitantly with levodopa or carbidopa-levodopa combination products, the most common adverse reactions have included dyskinesias such as choreiform, dystonic, and other involuntary movements, and nausea. Other adverse reactions reported with LODOSYN when administered concomitantly with levodopa alone or carbidopa-levodopa combination products were psychotic episodes including delusions, hallucinations, and paranoid ideation, depression with or without development of suicidal tendencies, and dementia. Convulsions also have occurred; however, a causal relationship with concomitant use of LODOSYN and levodopa has not been established.
The following other adverse reactions have been reported with levodopa and carbidopalevodopa combination products. These same adverse reactions may also occur when LODOSYN is administered with these products.
Body as a Whole: abdominal pain and distress, asthenia, chest pain, fatigue.
Gastrointestinal: anorexia, bruxism, burning sensation of the tongue, constipation, dark saliva, development of duodenal ulcer, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastrointestinal bleeding, gastrointestinal pain, heartburn, hiccups, sialorrhea, taste alterations, vomiting.
Metabolic: edema, weight gain, weight loss.
Musculoskeletal: back pain, leg pain, muscle cramps, shoulder pain.
Nervous System/Psychiatric: Psychotic episodes including delusions, hallucinations and paranoid ideation, neuroleptic malignant syndrome (NMS, see WARNINGS), bradykinetic episodes (“on-off” phenomenon), confusion, agitation, dizziness, somnolence, dream abnormalities including nightmares, insomnia, paresthesia, headache, depression with or without development of suicidal tendencies, dementia, pathological gambling, increased libido including hypersexuality, impulse control symptoms. Convulsions also have occurred; however, a causal relationship with LODOSYN and levodopa, has not been established.
Special Senses: oculogyric crises, diplopia, blurred vision, dilated pupils.
Laboratory Tests: abnormalities in alkaline phosphatase, SGOT (AST), SGPT (ALT), lactic dehydrogenase, bilirubin, blood urea nitrogen (BUN), Coombs test; elevated serum glucose; decreased hemoglobin and hematocrit; decreased white blood cell count and serum potassium; increased serum creatinine and uric acid; white blood cells, bacteria and blood in the urine; protein and glucose in the urine.
Read the entire FDA prescribing information for Lodosyn (Carbidopa)
Additional Lodosyn Information
Lodosyn - User Reviews
Lodosyn User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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