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Heparin Lock Flush
Heparin is a heterogenous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans, having anticoagulant properties. Although others may be present, the main sugars occurring in heparin are: (1) α-L-iduronic acid 2-sulfate, (2) 2-deoxy-2-sulfamino-α-D-glucose 6-sulfate, (3) β-D-glucuronic acid, (4) 2-acetamido-2-deoxy-α-D-glucose, and (5) α-L-iduronic acid. These sugars are present in decreasing amounts, usually in the order (2)> (1)> (4)> (3)> (5), and are joined by glycosidic linkages, forming polymers of varying sizes. Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups. In heparin sodium, the acidic protons of the sulfate units are partially replaced by sodium ions.
Its structural formula (representative subunits) is as follows:
Heparin Lock Flush Solution, USP, is a sterile solution of heparin sodium derived from porcine intestinal mucosa. Each mL contains either 10 or 100 USP heparin units in Water for Injection, benzyl alcohol 1% as a preservative, and sufficient sodium chloride to render the solution isotonic. The pH is adjusted between 5 to 7.5 with hydrochloric acid or sodium hydroxide.
Last reviewed on RxList: 8/8/2016
This monograph has been modified to include the generic and brand name in many instances.
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