"Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as the sensation of itch.
LoKara Side Effects Center
Medical Editor: Charles Patrick Davis, MD, PhD
Lokara (desonide 0.05%) lotion is a low to medium potency corticosteroid indicated for the relief of the inflammatory and pruritic (itching) manifestations of corticosteroid responsive dermatoses. Lokara is available in other countries as the generic desonide 0.05% lotion. Common side effects seen with Lokara use can include contact dermatitis, skin burning, peeling, irritation, dryness, and scaliness.
Each gram of LoKara Lotion (desonide lotion 0.05%) contains 0.5 mg of desonide in a lotion base in two sizes, 59 and 118ml. LoKara should be applied to the affected areas as a thin film two or three times daily depending on the severity of the condition. Therapy should be discontinued when control is achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. Severe side effects may include aspects of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.
It is also not known whether LoKara can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. LoKara should be given to a pregnant woman only if clearly needed. Because many drugs are excreted in human milk, caution should be exercised when LoKara is administered to a nursing woman. Safety and effectiveness has not been done for pediatric patients.
Our LoKara Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
LoKara in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medication and call your doctor at once if you have severe irritation of any treated skin, or if you show signs of absorbing desonide topical through your skin, such as:
- blurred vision, or seeing halos around lights;
- mood changes;
- sleep problems (insomnia);
- weight gain, puffiness in your face; or
- muscle weakness, feeling tired.
Less serious side effects may include:
- mild skin itching, redness, burning, or peeling;
- dryness or scaly skin;
- thinning or softening of your skin;
- skin rash or irritation around your mouth;
- swollen hair follicles;
- changes in color of treated skin;
- blisters, pimples, or crusting of treated skin; or
- stretch marks.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for LoKara (Desonide Lotion 0.05%)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
LoKara FDA Prescribing Information: Side Effects
In controlled clinical trials, the total incidence of adverse reactions associated with the use of desonide was approximately 8%. These were: stinging and burning approximately 3%, irritation, contact dermatitis, condition worsened, peeling of skin, itching, intense transient erythema, and dryness/scaliness, each less than 2%.
The following additional local adverse reactions have been reported infrequently with other topical corticosteroids, and they may occur more frequently with the use of occlusive dressings, especially with higher potency corticosteroids. These reactions are listed in an approximate decreasing order of occurrence: folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, secondary infection, skin atrophy, striae, and miliaria.
Read the entire FDA prescribing information for LoKara (Desonide Lotion 0.05%)
Additional LoKara Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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