Lomotil (Diphenoxylate and Atropine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Lomotil

Diarrhea »

Diarrhea facts

Diarrhea is an increase in the frequency of bowel movements, an increase in the looseness of stool or both.
Diarrhea is caused by increased secretion of fluid into the intestine, reduced absorption of fluid from the intestine or rapid passage of stool through the intestine.
Diarrhea can be defined absolutely or relatively. Absolute diarrhea is defined as more than five bowel movements a day or liquid stools. Relative diarrhea is defined as an increase in the number of bowel movements per day or an increase in the looseness of stools compared with an individual's usual bowel habit.
Diarrhea may be either acute or chronic, and each has different causes and treatments.
Complications of diarrhea include dehydration, electrolytes (mineral) abnormalities, and irritation of the anus.
Dehydration can be treated with oral ...

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Lomotil® CV
(diphenoxylate hydrochloride and atropine sulfate) Tablets, USP
(diphenoxylate hydrochloride and atropine sulfate liquid) Oral Solution, USP

DRUG DESCRIPTION

Each Lomotil (diphenoxylate and atropine) tablet and each 5 ml of Lomotil (diphenoxylate and atropine) liquid for oral use contains: diphenoxylate hydrochloride 2.5 mg atropine sulfate ..............0.025 mg

Diphenoxylate hydrochloride, an antidiarrheal, is ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate monohydrochloride and has the following structural formula:

Lomotil (Diphenoxylate hydrochloride) structural formula illustration 1

Atropine sulfate, an anticholinergic, is endo-(±)-α-(hydroxymethyl) benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1] oct-3-yl ester sulfate (2:1) (salt) monohydrate and has the following structural formula:

Lomotil (Diphenoxylate hydrochloride) structural formula illustration 2

A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage.

Inactive ingredients of Lomotil (diphenoxylate and atropine) tablets include acacia, corn starch, magnesium stearate, sorbitol, sucrose, and talc. Inactive ingredients of Lomotil (diphenoxylate and atropine) liquid include cherry flavor, citric acid, ethyl alcohol 15%, FD&C Yellow No. 6, glycerin, sodium phosphate, sorbitol, and water.

What are the possible side effects of atropine and diphenoxylate (Lomotil, Lonox, Vi-Atro)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

stomach pain or bloating;
ongoing or worsening diarrhea;
diarrhea that is watery or bloody;
numbness in your hands or feet;
depressed mood;
confusion, unusual thoughts or...

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What are the precautions when taking diphenoxylate and atropine (Lomotil)?

Before taking diphenoxylate with atropine, tell your doctor or pharmacist if you are allergic to either drug; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: liver disease (e.g., obstructive jaundice, cirrhosis), diarrhea caused by certain types of infections (Clostridium difficile-associated diarrhea following recent antibiotic therapy, bacterial infection of the gut caused by E. coli, Salmonella, Shigella).

Before using this medication, tell your doctor or pharmacist your medical history,...

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Last reviewed on RxList: 10/4/2010
This monograph has been modified to include the generic and brand name in many instances.