May 25, 2017
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Lomotil Patient Information Including Side Effects

Brand Names: Lomotil, Lonox, Vi-Atro

Generic Name: atropine and diphenoxylate (Pronunciation: A troe peen and DYE fen OX i late)

What is atropine and diphenoxylate (Lomotil)?

Atropine affects the body in many different ways, such as reducing spasms in the bladder, stomach, and intestines.

Diphenoxylate is an antidiarrheal medication.

The combination of atropine and diphenoxylate is used to treat diarrhea.

Atropine and diphenoxylate may also be used for other purposes not listed in this medication guide.

Atropine-Diphenoxylate 0.025 mg-2.5 mg-MYL

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What are the possible side effects of atropine and diphenoxylate (Lomotil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • stomach pain or bloating;
  • ongoing or worsening diarrhea;
  • diarrhea that is watery or bloody;
  • numbness in your hands or feet;
  • depressed mood;
  • confusion, unusual thoughts or behavior;
  • fast heart rate; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • drowsiness, dizziness, headache;
  • tired or restless feeling;
  • nausea, vomiting, upset stomach, loss of appetite; or
  • skin rash, or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the Lomotil (diphenoxylate and atropine) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about atropine and diphenoxylate (Lomotil)?

If you are giving this medication to a child, pay close attention to the dose. An atropine and diphenoxylate overdose is more likely to occur in a child, and can cause breathing problems or result in death or permanent brain damage.

Use only the liquid form of this medicine in a child younger than 13 years old. Do not give atropine and diphenoxylate tablets to a child under 13.

Drink extra water while you are taking this medication to keep from getting dehydrated.

It may take up to 48 hours of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 10 days of treatment.

Side Effects Centers

Lomotil - User Reviews

Lomotil User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Lomotil sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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