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Lomotil

Last reviewed on RxList: 1/9/2017
Lomotil Side Effects Center

Last reviewed on RxList 9/16/2016

Lomotil (diphenoxylate and atropine) is a combination antidiarrheal medication, and an anticholinergic used to treat diarrhea. Lomotil is available in generic form. Common side effects of Lomotil include:

  • drowsiness,
  • dizziness,
  • headache,
  • tiredness,
  • restlessness,
  • blurred vision,
  • dry mouth,
  • nausea,
  • vomiting,
  • upset stomach,
  • loss of appetite,
  • skin rash, or
  • itching.

Tell your doctor if you experience unlikely but serious side effects of Lomotil including:

  • stomach or abdominal pain or swelling,
  • severe nausea or vomiting,
  • mental/mood changes (e.g., confusion, depression), or
  • numbness and tingling of arms or legs.

The recommended initial adult dosage is two Lomotil tablets four times daily or 10 ml (two regular tsp) of Lomotil liquid four times daily (20 mg per day). The pediatric dose is determined by the child's weight. Lomotil may interact with barbiturates or MAO inhibitors. Lomotil may interact with other drugs. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Lomotil should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breastfeeding.

Our Lomotil (diphenoxylate and atropine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lomotil Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • stomach pain or bloating;
  • ongoing or worsening diarrhea;
  • diarrhea that is watery or bloody;
  • numbness in your hands or feet;
  • depressed mood;
  • confusion, unusual thoughts or behavior;
  • fast heart rate; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • drowsiness, dizziness, headache;
  • tired or restless feeling;
  • nausea, vomiting, upset stomach, loss of appetite; or
  • skin rash, or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Lomotil (Diphenoxylate and Atropine)

Lomotil Professional Information

SIDE EFFECTS

At therapeutic doses, the following have been reported; they are listed in decreasing order of severity, but not of frequency:

Nervous System

numbness of extremities, euphoria, depression, malaise/lethargy, confusion, sedation/drowsiness, dizziness, restlessness, headache.

Allergic

anaphylaxis, angioneurotic edema, urticaria, swelling of the gums, pruritus.

Gastrointestinal System

toxic megacolon, paralytic ileus, pancreatitis, vomiting, nausea, anorexia, abdominal discomfort.

The following atropine sulfate effects are listed in decreasing order of severity, but not of frequency: hyperthermia, tachycardia, urinary retention, flushing, dryness of the skin and mucous membranes. These effects may occur, especially in children.

THIS MEDICATION SHOULD BE KEPT IN A CHILD-RESISTANT CONTAINER AND OUT OF THE REACH OF CHILDREN SINCE AN OVERDOSAGE MAY RESULT IN SEVERE RESPIRATORY DEPRESSION AND COMA, POSSIBLY LEADING TO PERMANENT BRAIN DAMAGE OR DEATH.

Read the entire FDA prescribing information for Lomotil (Diphenoxylate and Atropine)

Related Resources for Lomotil

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Read the Lomotil User Reviews »

© Lomotil Patient Information is supplied by Cerner Multum, Inc. and Lomotil Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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