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(minoxidil) Tablets, USP
LONITEN Tablets contain the powerful antihypertensive agent, minoxidil, which may produce serious adverse effects. It can cause pericardial effusion, occasionally progressing to tamponade, and angina pectoris may be exacerbated. LONITEN should be reserved for hypertensive patients who do not respond adequately to maximum therapeutic doses of a diuretic and two other antihypertensive agents.
In experimental animals, minoxidil caused several kinds of myocardial lesions as well as other adverse cardiac effects (see Cardiac Lesions in Animals).
LONITEN must be administered under close supervision, usually concomitantly with therapeutic doses of a beta-adrenergic blocking agent to prevent tachycardia and increased myocardial workload. It must also usually be given with a diuretic, frequently one acting in the ascending limb of the loop of Henle, to prevent serious fluid accumulation. Patients with malignant hypertension and those already receiving guanethidine (see WARNINGS) should be hospitalized when LONITEN is first administered so that they can be monitored to avoid too rapid, or large orthostatic, decreases in blood pressure.
LONITEN Tablets contain minoxidil, an antihypertensive peripheral vasodilator. Minoxidil occurs as a white or off-white, odorless, crystalline solid that is soluble in water to the extent of approximately 2 mg/mL, is readily soluble in propylene glycol or ethanol, and is almost insoluble in acetone, chloroform or ethyl acetate. The chemical name for minoxidil is 2,4-pyrimidinediamine,6-(1-piperidinyl)-, 3-oxide (mw=209.25). The structural formula is represented at right:
LONITEN Tablets for oral administration contain either 2.5 mg or 10 mg of minoxidil. Inactive ingredients: cellulose, corn starch, lactose, magnesium stearate, silicon dioxide.
Last reviewed on RxList: 1/11/2017
This monograph has been modified to include the generic and brand name in many instances.
Additional Loniten Information
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