Lopid (Gemfibrozil) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 8, 2012

Lopid

Cholesterol »

Cholesterol facts

High cholesterol is also referred to as hypercholesterolemia (hyper=high + cholesterol + emia = in the blood) or hyperlipidemia
Cholesterol is a fatty substance that is an important part of the outer lining of cells in the body of animals.
Cholesterol is also found in the blood circulation of humans.
Cholesterol in the blood originates from dietary intake and liver production.
Dietary cholesterol comes primarily from animal sources including meat, poultry, fish, and dairy products.
Organ meats such as liver, are especially high in cholesterol content.
LDL (low density lipoprotein) cholesterol is called "bad" cholesterol, because elevated levels of LDL cholesterol are associated with an increased risk of coronary heart disease.
HDL (high density lipoprotein) cholesterol is called the "good cholesterol" because HDL cholesterol particles pre...

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LOPID®
(gemfibrozil) Tablets, USP

DRUG DESCRIPTION

LOPID® (gemfibrozil tablets, USP) is a lipid regulating agent. It is available as tablets for oral administration. Each tablet contains 600 mg gemfibrozil. Each tablet also contains calcium stearate, NF; candelilla wax, FCC; microcrystalline cellulose, NF; hydroxypropyl cellulose, NF; hypromellose, USP; methylparaben, NF; Opaspray white; polyethylene glycol, NF; polysorbate 80, NF; propylparaben, NF; colloidal silicon dioxide, NF; pregelatinized starch, NF. The chemical name is 5-(2,5-dimethylphenoxy)2,2-dimethylpentanoic acid, with the following structural formula:

LOPID®
(Gemfibrozil) Structural Formula Illustration

The empirical formula is C₁₅H₂₂O₃ and the molecular weight is 250.35; the solubility in water and acid is 0.0019% and in dilute base it is greater than 1%. The melting point is 58° –61°C. Gemfibrozil is a white solid which is stable under ordinary conditions.

What are the possible side effects of gemfibrozil (Lopid)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

sharp pain in your upper stomach (especially after eating);
jaundice (yellowing of your skin or eyes);
blurred vision, eye pain, or seeing halos around lights; or
pain or burning when you urinate.

Less serious side effects may include:

...

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What are the precautions when taking gemfibrozil (Lopid)?

Before taking gemfibrozil, tell your doctor or pharmacist if you are allergic to it; or to other "fibrates" (such as fenofibrate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (such as biliary cirrhosis), gallbladder disease, kidney disease, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for use during pregnancy. Consult your doctor for more details.

It is...

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Last reviewed on RxList: 10/25/2010
This monograph has been modified to include the generic and brand name in many instances.